Document Detail

Cortical involvement in marchiafava-bignami disease can be a predictor of a poor prognosis: a case report and review of the literature.
MedLine Citation:
PMID:  23545681     Owner:  NLM     Status:  In-Data-Review    
Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. We herein present the case of a 56-year-old man with chronic alcoholism who was admitted to our hospital in a coma without focal or lateralizing neurological signs. MRI revealed a callosal lesion consistent with MBD and additional bifrontal linear cortical lesions. The callosal lesion completely disappeared with intravenous administration of high-dose multivitamins and corticosteroids, although the patient remained in a vegetative state. This case further supports the notion that cortical involvement in patients with MBD is a predictor of a poor prognosis.
Michito Namekawa; Yuko Nakamura; Imaharu Nakano
Publication Detail:
Type:  Journal Article     Date:  2013-04-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  52     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  811-3     Citation Subset:  IM    
Department of Neurology, Jichi Medical University, Japan.
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