| Cortical interneurons require p35/Cdk5 for their migration and laminar organization. | |
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MedLine Citation:
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PMID: 19037081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Projection neurons and interneurons populate the cerebral cortex in a layer-specific manner. Here, we studied the role of Cyclin-dependent kinase 5 (Cdk5) and its activator p35 in cortical interneuron migration and disposition in the cortex. We found that mice lacking p35 (p35(-/-)) show accumulation of interneurons in the upper part of the cortex. We also observed an inverted distribution of both early- and late-born interneurons, with the former showing a preference for the upper and the latter for the lower aspects of the cortex. We investigated the causes of the altered laminar organization of interneurons in p35(-/-) mice and found a cell-autonomous delay in their tangential migration that may prevent them from reaching correct positions. Incomplete splitting of the preplate in p35(-/-) mice, which causes accumulation of cells in the superficial layer and defects in the "inward" and "outward" components of their radial movement, may also account for the altered final arrangement of interneurons. We, therefore, propose that p35/Cdk5 plays a key role in guiding cortical interneurons to their final positions in the cortex. |
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Authors:
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Sonja Rakić; Yuchio Yanagawa; Kunihiko Obata; Clare Faux; John G Parnavelas; Margareta Nikolić |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-26 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: 19 ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-06 Completed Date: 2009-09-16 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: United States |
Other Details:
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Languages: eng Pagination: 1857-69 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cell Movement / physiology* Cells, Cultured Cerebral Cortex / growth & development*, metabolism, physiology Cyclin-Dependent Kinase 5 / metabolism* Immunohistochemistry Interneurons / metabolism, physiology* Mice Mice, Knockout Mice, Neurologic Mutants Mice, Transgenic Microscopy, Fluorescence Nerve Tissue Proteins / metabolism* Neurons / cytology |
| Grant Support | |
ID/Acronym/Agency:
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069441//Wellcome Trust; 074549//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 0/neuronal Cdk5 activator (p25-p35); EC 2.7.1.37/Cdk5 protein, mouse; EC 2.7.11.22/Cyclin-Dependent Kinase 5 |
| Comments/Corrections | |
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