Document Detail

Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness.
MedLine Citation:
PMID:  15953273     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The pathophysiological relationship between episodic migraine and chronic migraine is not fully understood. We aimed to examine transcranial magnetic stimulation (TMS) indices of cortical excitability in patients with episodic migraine (EM) and probable chronic migraine (PCM), and matched controls. METHODS: Cortical excitability was assessed at baseline with two well-established methods: phosphene thresholds (PT) and magnetic suppression of perceptual accuracy (MSPA) profiles. Five EM patients, five PCM patients, and five normal controls participated in the main study. In addition, two patients were reassessed after 30 days of treatment with topiramate. RESULTS: Both PT and MPSA measures were consistent in indicating a continuum of excitability across the three groups: PCM patients had the highest excitability, followed by EM, then controls. In the two treated patients MPSA profiles appeared to normalize at a 100 mg dosage. CONCLUSIONS: Patients with PCM appear to be characterized by very high cortical excitability. This may contribute to their greatly increased attack frequency. TMS-based methods will be important for future research examining the evolution of chronic migraine from episodic migraine over time.
Sheena K Aurora; Patricia Barrodale; Edward P Chronicle; Wim M Mulleners
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Headache     Volume:  45     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-14     Completed Date:  2005-09-26     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-52     Citation Subset:  IM    
Swedish Headache Center, Seattle, WA 98104, and University of Hawaii at Manoa, Department of Psychology, Honolulu, USA.
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MeSH Terms
Cerebral Cortex / physiopathology*
Chronic Disease
Magnetoencephalography / instrumentation,  methods
Migraine Disorders / physiopathology*
Phosphenes / physiology

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