Document Detail

Cortical glucose metabolism in Huntington's disease.
MedLine Citation:
PMID:  1531155     Owner:  NLM     Status:  MEDLINE    
We measured cortical glucose metabolism with positron emission tomography in 39 patients with Huntington's disease (HD) and in 34 controls. In the 23 patients with symptoms for less than 5 years, there was a 15% decrease in metabolism in frontal and inferior parietal cortex. In 16 patients with symptoms for more than 5 years, all cortical areas (except temporal) were significantly involved, with metabolic rates 25 to 30% below those of controls. These data indicate the presence of a diffuse abnormality of cortical function with early involvement of frontal lobes in HD, suggesting that the clinical manifestations may not be related solely to basal ganglia pathology, even in early disease.
W R Martin; C Clark; W Ammann; A J Stoessl; W Shtybel; M R Hayden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  42     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-02     Completed Date:  1992-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-9     Citation Subset:  AIM; IM    
Department of Medicine (Neurology), University of Alberta, Edmonton, Canada.
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MeSH Terms
Cerebral Cortex / metabolism*,  radionuclide imaging
Deoxyglucose / analogs & derivatives
Fluorodeoxyglucose F18
Glucose / metabolism*
Huntington Disease / metabolism*,  radionuclide imaging
Middle Aged
Tissue Distribution
Tomography, Emission-Computed*
Reg. No./Substance:
154-17-6/Deoxyglucose; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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