Document Detail


Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventions.
MedLine Citation:
PMID:  22708598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schizophrenia is a devastating disorder that is common, usually chronic, frequently associated with substantial co-morbidity for addictive and medical disorders and, as a consequence, very costly in both personal and economic terms. At present, no proven means for preventing or modifying the course of the illness exist. This review discusses evidence supporting the ideas that: (i) impairments in certain cognitive processes are the core feature of schizophrenia; (ii) these cognitive impairments reflect abnormalities in specific cortical circuits; and (iii) these circuitry abnormalities arise during childhood-adolescence. The implications of these findings for the development and implementation of safe, preemptive, disease-modifying interventions in individuals at high risk for a clinical diagnosis of schizophrenia are considered.
Authors:
David A Lewis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  35     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-19     Completed Date:  2012-11-09     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1871-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Author. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Affiliation:
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Biomedical Science Tower W1654, Pittsburgh, PA 15213, USA. lewisda@upmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Animals
Child
Cognition Disorders / complications,  physiopathology
Early Medical Intervention
Humans
Interneurons / physiology
Prefrontal Cortex / growth & development,  physiopathology*
Rats
Schizophrenia / complications,  physiopathology*,  therapy*
Grant Support
ID/Acronym/Agency:
MH043784/MH/NIMH NIH HHS; MH051234/MH/NIMH NIH HHS; MH084053/MH/NIMH NIH HHS; P50 MH084053/MH/NIMH NIH HHS; R01 MH043784/MH/NIMH NIH HHS; R01 MH051234/MH/NIMH NIH HHS; R37 MH043784/MH/NIMH NIH HHS
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