Document Detail

Cortical cholinergic denervation is associated with depressive symptoms in Parkinson's disease and parkinsonian dementia.
MedLine Citation:
PMID:  17507447     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the relationship between ratings of depressive symptoms and in vivo cortical acetylcholinesterase (AChE) activity in subjects with Parkinson's disease (PD) and parkinsonian dementia (PDem).
METHODS: Subjects (with PD, n = 18, including subjects with PDem, n = 6, and normal controls, n = 10) underwent [11C]methyl-4-piperidinyl propionate AChE positron emission tomography imaging and clinical assessment including the Cornell Scale for Depression in Dementia (CSDD).
RESULTS: Subjects with PD and PDem had higher scores on the CSDD compared with normal controls: 7.3 (5.4) and 2.8 (2.6), respectively (F = 6.9, p = 0.01). Pooled analysis demonstrated a significant inverse correlation between cortical AChE activity and CSDD scores: R = -0.5, p = 0.007. This correlation remained significant after controlling for Mini-Mental State Examination scores.
CONCLUSION: Depressive symptomatology is associated with cortical cholinergic denervation in PD that tends to be more prominent when dementia is present.
N I Bohnen; D I Kaufer; R Hendrickson; G M Constantine; C A Mathis; R Y Moore
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  78     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-17     Completed Date:  2007-05-24     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  641-3     Citation Subset:  IM    
Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Acetylcholinesterase / metabolism*
Aged, 80 and over
Cerebral Cortex / physiopathology
Cholinergic Agents / metabolism*
Dementia / etiology,  physiopathology*,  radionuclide imaging
Depressive Disorder / etiology,  physiopathology*,  radionuclide imaging
Magnetic Resonance Imaging
Nerve Degeneration / physiopathology,  radionuclide imaging
Neuropsychological Tests
Parkinson Disease / complications,  physiopathology*,  radionuclide imaging
Positron-Emission Tomography
Receptors, Cholinergic / metabolism
Grant Support
Reg. No./Substance:
0/Cholinergic Agents; 0/Receptors, Cholinergic; EC

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