Document Detail


Cortical and cerebellar modulation of autonomic responses to loud sounds.
MedLine Citation:
PMID:  24016238     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Detecting unexpected environmental change causes modulation of autonomic activity essential for survival. Understanding the neural mechanisms associated with responses to loud sounds may provide insights into the pathophysiology of posttraumatic stress disorder (PTSD), since individuals with PTSD exhibit heightened autonomic responses to unexpected loud sounds. We combined fMRI with autonomic psychophysiological assessment to investigate central and peripheral reactivity to loud tones in 20 healthy participants. Activity in anterior insula, pregenual anterior cingulate cortex, anterior midcingulate cortex, supplementary motor area, supramarginal gyrus, and cerebellar lobules VIII-IX was associated with both tones and concomitant skin conductance responses. Since regions signaling unexpected external events modulate autonomic activity, heightened loud tone autonomic responses in PTSD may reflect sensitization of this "salience" network.
Authors:
Christoph Mueller-Pfeiffer; Thomas Zeffiro; Ruth O'Gorman; Lars Michels; Peter Baumann; Nellie Wood; Justin Spring; Michael Rufer; Roger K Pitman; Scott P Orr
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-9
Journal Detail:
Title:  Psychophysiology     Volume:  -     ISSN:  1540-5958     ISO Abbreviation:  Psychophysiology     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Society for Psychophysiological Research.
Affiliation:
Department of Psychiatry and Psychotherapy, University Hospital Zurich, Zurich, Switzerland; Center of Education and Research (COEUR), Psychiatric Services of the County of St. Gallen-North, Wil, Switzerland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
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