Document Detail


The cortical response to the oral perception of fat emulsions and the effect of taster status.
MedLine Citation:
PMID:  21389303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rewarding attributes of foods containing fat are associated with the increase in fat consumption, but little is known of how the complex physical and chemical properties of orally ingested fats are represented and decoded in the brain nor how this impacts feeding behavior within the population. Here, functional MRI (fMRI) is used to assess the brain response to isoviscous, isosweet fat emulsions of increasing fat concentration and to investigate the correlation of behavioral and neuroimaging responses with taster status (TS). Cortical areas activated in response to fat, and those areas positively correlated with fat concentration, were identified. Significant responses that positively correlated with increasing fat concentration were found in the anterior insula, frontal operculum and secondary somatosensory cortex (SII), anterior cingulate cortex, and amygdala. Assessing the effect of TS revealed a strong correlation with self-reported preference of the samples and with cortical response in somatosensory areas [primary somatosensory cortex (SI), SII, and midinsula] and the primary taste area (anterior insula) and a trend in reward areas (amygdala and orbitofrontal cortex). This finding of a strong correlation with TS in somatosensory areas supports the theory of increased mechanosensory trigeminal innervation in high 6-n-propyl-2-thiouracil (PROP) tasters and has been linked to a higher risk of obesity. The interindividual differences in blood oxygenation level-dependent (BOLD) amplitude with TS indicates that segmenting populations by TS will reduce the heterogeneity of BOLD responses, improving signal detection power.
Authors:
Sally Eldeghaidy; Luca Marciani; Francis McGlone; Tracey Hollowood; Joanne Hort; Kay Head; Andrew J Taylor; Johanneke Busch; Robin C Spiller; Penny A Gowland; Susan T Francis
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-03-09
Journal Detail:
Title:  Journal of neurophysiology     Volume:  105     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-18     Completed Date:  2012-04-17     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2572-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Cortex / physiology*
Dietary Fats / administration & dosage*
Emulsifying Agents / administration & dosage*
Emulsions
Female
Humans
Magnetic Resonance Imaging / methods
Male
Mouth / physiology*
Taste / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
BB/D522862/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Emulsifying Agents; 0/Emulsions
Comments/Corrections

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