Document Detail


Cortical activation pattern in hemiparetic patients with pontine infarct.
MedLine Citation:
PMID:  20558983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: No prior study has reported on the cortical activation pattern in hemiparetic patients with a pontine infarct. The aim of this study was to investigate the cortical activation pattern of hemiparetic patients with a pontine infarct, using functional MRI scanning (fMRI). SUBJECTS AND METHOD: Fifteen consecutive patients who showed severe weakness at onset due to a pontine infarct were recruited. The motor function was assessed at the time of the onset of stroke and fMRI scanning was performed (on average 8.9 months after stroke onset). The fMRI was performed during a motor task of timed hand grasp-release movements. From the fMRI, the laterality index was calculated to assess the relative activity in the ipsilateral versus the contralateral primary sensorimotor cortex (SM1). RESULTS: All patients except for 2 (bilateral SM1 activation) showed contralateral SM1 activation without ipsilateral SM1 activation associated with the affected hand movements. The average laterality index for the affected hand movements among all patients was 0.97. CONCLUSIONS: The fMRI results showed that primarily the contralateral SM1 was activated during affected hand movements. Therefore, it appears that the motor function of the affected hand, in patients with a pontine infarct, recovers mainly via the lateral corticospinal tract.
Authors:
Yong Hyun Kwon; Sung Ho Jang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-19
Journal Detail:
Title:  European neurology     Volume:  64     ISSN:  1421-9913     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Affiliation:
Department of Physical Therapy, Yeungnam University, Taegu, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Infarction / complications*,  pathology
Cerebral Cortex / blood supply,  pathology,  physiopathology*
Chi-Square Distribution
Female
Functional Laterality / physiology*
Hand / innervation,  physiopathology
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods
Male
Mental Status Schedule
Middle Aged
Motor Activity / physiology
Neurologic Examination / methods
Oxygen / blood
Paresis / complications*,  pathology
Pons / blood supply,  pathology*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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