| Cortex mediates multisensory but not unisensory integration in superior colliculus. | |
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MedLine Citation:
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PMID: 18032649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Converging cortical influences from the anterior ectosylvian sulcus and the rostral lateral suprasylvian sulcus were shown to have a multisensory-specific role in the integration of sensory information in superior colliculus (SC) neurons. These observations were based on changes induced by cryogenic deactivation of these cortico-SC projections. Thus, although the results indicated that they played a critical role in integrating SC responses to stimuli derived from different senses (i.e., visual-auditory), they played no role in synthesizing its responses to stimuli derived from within the same sense (visual-visual). This was evident even in the same multisensory neurons. The results suggest that very different neural circuits have evolved to code combinations of cross-modal and within-modal stimuli in the SC, and that the differences in multisensory and unisensory integration are likely caused by differences in the configuration of each neuron's functional inputs rather than to any inherent differences among the neurons themselves. The specificity of these descending influences was also apparent in the very different ways in which they affected responses to the component cross-modal stimuli and their actual integration. Furthermore, they appeared to target only multisensory neurons and not their unisensory neighbors. |
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Authors:
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Juan Carlos Alvarado; Terrence R Stanford; J William Vaughan; Barry E Stein |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 27 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-22 Completed Date: 2007-12-18 Revised Date: 2008-03-19 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 12775-86 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. jalvarad@wfubmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Animals Auditory Perception / physiology Cats Cerebral Cortex / physiology* Neurons, Afferent / physiology* Photic Stimulation / methods Superior Colliculi / physiology* Visual Perception / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY016716/EY/NEI NIH HHS; NS22543/NS/NINDS NIH HHS; NS36916/NS/NINDS NIH HHS |
| Comments/Corrections | |
Comment In:
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J Neurosci. 2008 Feb 20;28(8):1787-8
[PMID:
18287494
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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