Document Detail


Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus procedures.
MedLine Citation:
PMID:  15734516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Magnetic resonance imaging (MRI) and microelectrode recording (MER) are commonly used to guide stereotactic procedures on the subthalamic nucleus (STN). Little is known about the correlation between the position of the STN as seen on MRI and that as determined by MER mapping. We compared these in 10 patients with Parkinson's disease. METHODS: The position of the STN was determined by intraoperative MER findings and stereotactic axial T2 magnetic resonance images with 2-mm slice thickness. Images were reconstructed in a 3-dimensional workstation. The anterior, posterior, medial, lateral, dorsal, and ventral borders of the STN defined with the MRI were measured relative to the midcommissural point. The location of STN activity during MER was reconstructed relative to the midcommissural point for comparison. RESULTS: Twenty-nine tracks recorded with microelectrodes provided clear spans of STN-like activity in 18 STN nuclei. The coordinates of MER were, in general, within the borders of the STN defined with the MRI. However, when analyzed individually, some of the tracks had STN-like activity outside the borders of the MRI-defined nucleus (mostly <1 mm). Three tracks had STN-like activity recorded between 2 and 3 mm more anterior than the anterior border of the nucleus defined with the MRI. CONCLUSIONS: There was a good correlation between MER and the borders of the STN defined in the MRI, except for the anterior-posterior axis, in which MER indicated that the STN extended more anteriorly than as suggested by MRI. This should be taken into account in STN surgery.
Authors:
Clement Hamani; Erich O Richter; Yuri Andrade-Souza; William Hutchison; Jean A Saint-Cyr; Andres M Lozano
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  63     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-53; discussion 253     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, University of Toronto, Toronto, ON M5T 2S8, Canada. c.hamani@sympatico.ca
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Brain Mapping / instrumentation,  methods*
Electrophysiology / instrumentation,  methods
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / instrumentation,  methods*
Medical Illustration
Microelectrodes / standards
Neural Pathways / physiopathology
Neurons / physiology
Parkinson Disease / pathology,  physiopathology,  surgery*
Reproducibility of Results
Retrospective Studies
Statistics as Topic
Stereotaxic Techniques / instrumentation*
Subthalamic Nucleus / anatomy & histology*,  physiopathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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