Document Detail

Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells.
MedLine Citation:
PMID:  18456406     Owner:  NLM     Status:  MEDLINE    
Altered Notch signaling seems linked with medulloblastoma (MB) formation and resveratrol exhibits anti-medulloblastoma effects. However, the influence of resveratrol in Notch signaling of MB cells has not been described. This issue was addressed here by checking Notch1 and Notch2 statuses in three MB cell lines with and without resveratrol treatment. Notch1 and Notch2 were detected in the cytoplasm of three cell lines under normal condition, which were up-regulated by resveratrol along with differentiation, apoptosis and enhanced Hes1 nuclear translocation. Nevertheless, blockage of Notch enzymatic cleavage with gamma-seacretase inhibitors, DAPT and L-685,458, neither interrupted resveratrol-caused cellular events nor affected MB cell growth. These results demonstrate that Notch signaling has little relevance with resveratrol-induced differentiation and apoptosis and may not be a universal critical factor of MB cells.
Qian Wang; Hong Li; Nan Liu; Xiao-Yan Chen; Mo-Li Wu; Kai-Li Zhang; Qing-You Kong; Jia Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-09
Journal Detail:
Title:  Neuroscience letters     Volume:  438     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-09-19     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Department of Cell Biology and Liaoning Laboratory of Cancer Genomics, College of Basic Medical Sciences, Dalian Medical University, 116044 Dalian, PR China.
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MeSH Terms
Active Transport, Cell Nucleus / drug effects,  physiology
Amyloid Precursor Protein Secretases / antagonists & inhibitors,  metabolism
Antineoplastic Agents / pharmacology,  therapeutic use
Antioxidants / pharmacology,  therapeutic use
Apoptosis / drug effects,  physiology
Basic Helix-Loop-Helix Transcription Factors / drug effects,  metabolism
Brain Neoplasms / drug therapy,  metabolism*
Cell Differentiation / drug effects,  physiology
Cell Line, Tumor
Cell Proliferation / drug effects
Cytoplasm / drug effects,  metabolism
Enzyme Inhibitors / pharmacology
Homeodomain Proteins / drug effects,  metabolism
Medulloblastoma / drug therapy,  metabolism*
Receptor, Notch1 / drug effects,  metabolism
Receptor, Notch2 / drug effects,  metabolism
Receptors, Notch / metabolism*
Signal Transduction / drug effects,  physiology*
Stilbenes / pharmacology*,  therapeutic use
Up-Regulation / drug effects,  physiology
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Enzyme Inhibitors; 0/Homeodomain Proteins; 0/NOTCH1 protein, human; 0/NOTCH2 protein, human; 0/Receptor, Notch1; 0/Receptor, Notch2; 0/Receptors, Notch; 0/Stilbenes; 149348-15-2/HES1 protein, human; EC 3.4.-/Amyloid Precursor Protein Secretases; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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