| Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study. | |
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MedLine Citation:
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PMID: 20561611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Risk for hypertension and diabetes has not been conclusively found to be a result of cadmium exposure. A population-based study was conducted in 2009 to examine the correlations of urinary cadmium, a good biomarker of long-term cadmium exposure, with hypertension and diabetes in persons aged 35 years and older who lived in the 12 cadmium-contaminated rural villages in northwestern Thailand. A total of 5273 persons were interviewed and screened for urinary cadmium, hypertension, and diabetes. The geometric mean level of urinary cadmium for women (2.4+/-2.3 microg/g creatinine) was significantly greater than that for men (2.0+/-2.2 microg/g creatinine). Hypertension was presented in 29.8% of the study population and diabetes was detected in 6.6%. The prevalence of hypertension significantly increased from 25.0% among persons in the lowest tertile of urinary cadmium to 35.0% in the highest tertile. In women, the rate of hypertension significantly increased with increasing urinary cadmium levels in both ever and never smokers, after adjusting for age, alcohol consumption, body mass index, and diabetes. In men, such association was less significantly found in never smokers. The study revealed no significant association between urinary cadmium and diabetes in either gender. Our study supports the hypothesis that environmental exposure to cadmium may increase the risk of hypertension. Risk for diabetes in relation to cadmium exposure remains uncertain in this exposed population. |
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Authors:
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Witaya Swaddiwudhipong; Pranee Mahasakpan; Pisit Limpatanachote; Somyot Krintratun |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-19 |
Journal Detail:
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Title: Environmental research Volume: 110 ISSN: 1096-0953 ISO Abbreviation: Environ. Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 612-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Community and Social Medicine, Mae Sot General Hospital, Tak 63110, Thailand. swaddi@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cadmium / toxicity, urine* Diabetes Mellitus / epidemiology*, urine Environmental Monitoring Environmental Pollutants / toxicity, urine* Environmental Pollution / statistics & numerical data Female Humans Hypertension / epidemiology*, urine Male Middle Aged Thailand / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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