| Correlations of serum CA125 level and computerized tomography (CT) imaging with laparotomic findings following intraperitoneal chemotherapy in patients with ovarian cancer. | |
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MedLine Citation:
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PMID: 11214619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the role of serum CA125 levels and computerized tomography (CT) scans in predicting pathologic response of intraperitoneal chemotherapy in patients with ovarian cancer. We prospectively analyzed serum CA125 levels and abdominopelvic CT scans obtained after the completion of intraperitoneal chemotherapy in 52 patients with ovarian cancer and compared the results with subsequent laparotomic findings, which served as the gold standard for statistical analysis. Laparatomy revealed either microscopic or macroscopic residual disease in 20 patients, while 32 patients were completely tumor-free. CA125 levels correlated significantly with laparotomic findings (p=0.003, u=1405). Median CA125 values in patients with residual tumors and in tumor-free patients following intraperitoneal chemotherapy were 14.6 (1-775) and 7.2 (1-37) U/ml, respectively. Although CT-imaging and CA 125 levels had a high specificity (100% and 96.9%, respectively), they showed a low sensitivity rate (50% and 40%, respectively). Similarly, despite high positive predictive values (100% and 88.9%, respectively), the negative predictive values were 76.2% and 72.1%, respectively. Conclusion: Although highly specific, CT scans and CA125 levels do not accurately indicate the presence of disease. Due to a high false-negative rate, a normal CT scan or a normal CA125 value is not sufficient to replace a laparotomy. |
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Authors:
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E Topuz; A Aydiner; P Saip; Y Eralp; F Taş; Y Salihoğlu; N Tenekeci |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of gynaecological oncology Volume: 21 ISSN: 0392-2936 ISO Abbreviation: Eur. J. Gynaecol. Oncol. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-02-14 Completed Date: 2001-05-17 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8100357 Medline TA: Eur J Gynaecol Oncol Country: Italy |
Other Details:
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Languages: eng Pagination: 599-602 Citation Subset: IM |
Affiliation:
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Institute of Oncology, University of Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Combined Chemotherapy Protocols / administration & dosage, therapeutic use* CA-125 Antigen / blood* Chemotherapy, Adjuvant Cystadenocarcinoma, Papillary / diagnosis*, drug therapy, immunology, radiography, surgery Female Humans Infusions, Parenteral Laparotomy Middle Aged Neoplasm Staging Ovarian Neoplasms / diagnosis*, drug therapy, immunology, radiography, surgery Predictive Value of Tests Prospective Studies Sensitivity and Specificity Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/CA-125 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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