Document Detail

Correlations between serum zinc concentrations and oxygen balance parameters in patients with primary arterial hypertension.
MedLine Citation:
PMID:  17625242     Owner:  NLM     Status:  MEDLINE    
It has been postulated that increased blood pressure is related to hypersensitivity of arterial chemoreceptors and increased tissue oxygen supply. Arterial blood pressure has been found to be negatively correlated to serum zinc and positively correlated to age, body mass index, and hemoglobin concentrations. The aim of the present investigation was to further explore the relationship between blood pressure and zinc concentrations in serum and blood morphology parameters, iron concentrations, and venous blood gasometry parameters. The study was carried out in two groups. Group Aconsisted of 23 subjects of both sexes suffering from moderate to severe arterial blood pressure. Their mean age was 53.13+/-10.45 yr (range: 23-74 yr). Group B included 48 subjects of mean age 36.7+/-10.0 yr (range: 26-60 yr). This group included 5 patients with arterial hypotension, 37 with hypertension, and the remaining 6 with normal blood pressure. Significant positive correlations between serum zinc and red blood cell count (r = 0.51) and negative with age (r = -0.52) were found. By multiple regression, negative correlations were also found between serum zinc and the diastolic blood pressure and with hemoglobin (r = -0.5). Age was positively correlated to systolic (r = 0.49) and diastolic (r = 0.45) blood pressure parameters and to hemoglobin concentrations (r = 0.33 and r = 0.38, respectively). Buffered and excess bases in blood were negatively correlated to zinc (r = -0.29 in both cases) and to systolic and diastolic blood pressure (r = -0.31 and r = -0.40, respectively). In turn, the systolic and diastolic blood pressure also correlated negatively to the partial pressure of carbon dioxide and positively to venous blood oxygen saturation and to the partial pressure of oxygen. The role of zinc and acid-balance realtionships in blood pressure regulation and in arterial hypertension ethiopatogenesis is disscused.
Slawomir Tubek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  115     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-07-12     Completed Date:  2007-08-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  IM    
Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, and Clinic of Cardiology, Medical Academy, Wroclaw, Prószkowska Street 76, 45-758 Opole, Poland.
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MeSH Terms
Blood Pressure
Body Mass Index
Cytosol / metabolism
Erythrocytes / cytology
Hypertension / metabolism*
Middle Aged
Oxygen / metabolism*
Zinc / blood*,  metabolism
Reg. No./Substance:
0/Ions; 7440-66-6/Zinc; 7782-44-7/Oxygen

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