Document Detail

Correlations between serum osmolality and endolymphatic sac response using hypertonic glycerol.
MedLine Citation:
PMID:  8336917     Owner:  NLM     Status:  MEDLINE    
This study, using mice, correlated serum osmotic pressure, experimentally elevated with an intravenous injection of glycerol of varying tonicity (1.3, 2.6 and 5.2 g glycerol/kg body weight) with endolymphatic sac (ES) response. The injection produced a rise in serum osmotic pressure that was measured after 15 min (from 308 +/- 12.9 mosm/kg b.w. to 320 +/- 1.9, 353 +/- 19.3, 427 +/- 9.4 mosm/kg b.w., respectively). Normal levels were noted about 60 min after the injection. The ES was graphically displayed at 0 min, 1, 2 and 4 h using as a basis composite electron micrographs. The ES responded with signs of active secretion and degradation of macromolecular substances which appeared to be related to the rise in serum osmotic pressure. The study showed that the ES responds to glycerol injection with fine structural changes indicative of increased intra-epithelial synthesis of sugar/protein residues which are secreted and degraded within its lumen. The technique used made it possible to characterize the ultrastructural secretory pathways from the epithelial cells into the sac lumen. The results indicate that the ES may sense and respond to dynamic changes of the micro-osmotic environment probably via alterations in inner ear fluid homeostasis.
B Jansson; H Rask-Anderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  55     ISSN:  0301-1569     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-08-26     Completed Date:  1993-08-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Department of Otolaryngology, University Hospital of Uppsala, Sweden.
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MeSH Terms
Endolymphatic Sac / drug effects,  physiology*,  ultrastructure
Glycerol / pharmacology*
Hypertonic Solutions / pharmacology
Microscopy, Electron
Osmolar Concentration
Osmotic Pressure
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Hypertonic Solutions; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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