| Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites. | |
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MedLine Citation:
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PMID: 12372654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is evidence for membrane abnormalities in schizophrenia. It is unclear whether the observed membrane deficits in peripheral cells parallel central membrane phospholipid metabolism. To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects. METHODS: Red blood cell membrane fatty acids were measured by capillary gas chromatography and in vivo brain phospholipid metabolite levels were measured using a multi-voxel (31)P Magnetic Resonance Spectroscopy technique on 11 first-episode, neuroleptic-naïve schizophrenic subjects and 11 normal control subjects. RESULTS: Both the total polyunsaturated fatty acids and the individual 20:4(n-6) contents were significantly correlated with the freely-mobile phosphomonoester [PME(s-tau(c))] levels (r =.5643, p =.0062 and r =.6729, p =.0006, respectively). The 18:2(n-6) polyunsaturated fatty acids content correlated positively with freely-mobile phosphodiester [PDE(s-tau(c))] levels (r =.5573, p =.0071). The above correlations were present in the combined right and left prefrontal region of the brain, while other regions including the basal ganglia, occipital, inferior parietal, superior temporal and centrum semiovale yielded no significant correlations. CONCLUSIONS: Our preliminary data support the association between the decreased red blood cell membrane phospholipid polyunsaturated fatty acids content and the decreased building blocks [PME(s-tau(c))] and breakdown products [PDE(s-tau(c))] of membrane phospholipids in the prefrontal region of first-episode, neuroleptic-naïve schizophrenic subjects. |
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Authors:
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Jeffrey k Yao; Jeffrey A Stanley; Ravinder D Reddy; Matcheri S Keshavan; Jay W Pettegrew |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 52 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-09 Completed Date: 2002-12-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 823-30 Citation Subset: IM |
Affiliation:
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Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / metabolism* Chromatography, Gas Erythrocyte Membrane / metabolism Fatty Acids, Unsaturated / blood, metabolism* Female Humans Magnetic Resonance Spectroscopy Male Phospholipids / metabolism* Prefrontal Cortex / metabolism Schizophrenia / diagnosis*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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MH 45203/MH/NIMH NIH HHS; MH 46614/MH/NIMH NIH HHS; MH 58141/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Phospholipids |
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