Document Detail


Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites.
MedLine Citation:
PMID:  12372654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is evidence for membrane abnormalities in schizophrenia. It is unclear whether the observed membrane deficits in peripheral cells parallel central membrane phospholipid metabolism. To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects. METHODS: Red blood cell membrane fatty acids were measured by capillary gas chromatography and in vivo brain phospholipid metabolite levels were measured using a multi-voxel (31)P Magnetic Resonance Spectroscopy technique on 11 first-episode, neuroleptic-naïve schizophrenic subjects and 11 normal control subjects. RESULTS: Both the total polyunsaturated fatty acids and the individual 20:4(n-6) contents were significantly correlated with the freely-mobile phosphomonoester [PME(s-tau(c))] levels (r =.5643, p =.0062 and r =.6729, p =.0006, respectively). The 18:2(n-6) polyunsaturated fatty acids content correlated positively with freely-mobile phosphodiester [PDE(s-tau(c))] levels (r =.5573, p =.0071). The above correlations were present in the combined right and left prefrontal region of the brain, while other regions including the basal ganglia, occipital, inferior parietal, superior temporal and centrum semiovale yielded no significant correlations. CONCLUSIONS: Our preliminary data support the association between the decreased red blood cell membrane phospholipid polyunsaturated fatty acids content and the decreased building blocks [PME(s-tau(c))] and breakdown products [PDE(s-tau(c))] of membrane phospholipids in the prefrontal region of first-episode, neuroleptic-naïve schizophrenic subjects.
Authors:
Jeffrey k Yao; Jeffrey A Stanley; Ravinder D Reddy; Matcheri S Keshavan; Jay W Pettegrew
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  52     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-09     Completed Date:  2002-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823-30     Citation Subset:  IM    
Affiliation:
Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / metabolism*
Chromatography, Gas
Erythrocyte Membrane / metabolism
Fatty Acids, Unsaturated / blood,  metabolism*
Female
Humans
Magnetic Resonance Spectroscopy
Male
Phospholipids / metabolism*
Prefrontal Cortex / metabolism
Schizophrenia / diagnosis*,  metabolism*
Grant Support
ID/Acronym/Agency:
MH 45203/MH/NIMH NIH HHS; MH 46614/MH/NIMH NIH HHS; MH 58141/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Phospholipids

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