Document Detail

Correlations between deviations from expected cirrhosis mortality and serum uric acid and dietary protein intake.
MedLine Citation:
PMID:  3724164     Owner:  NLM     Status:  MEDLINE    
Mortality from cirrhosis in many countries deviates markedly from that expected for a given per capita alcohol intake. Since lipid peroxidation is thought to be one of the mechanisms involved in the pathogenesis of liver disease and since uric acid is a natural antioxidant, we investigated the possibility that deviation in mortality rates from cirrhosis in different countries might be related to serum uric acid levels in the populations studied. Deviations from expected cirrhosis mortality were calculated as a percentage and correlated with the serum uric acid levels in nine countries. Since animal protein is a major source of dietary purines, the percentage deviation was also correlated with animal protein intake (g/capita/day) for 15 countries. Significant Pearson r correlations were obtained between the percentage deviation in cirrhosis mortality and serum uric acid (-.70, p less than .05) and animal protein ingestion (-.67, p less than .02). This suggests that higher levels of serum uric acid or higher intake of protein may protect against the development of cirrhosis.
A A Nanji; S W French
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of studies on alcohol     Volume:  47     ISSN:  0096-882X     ISO Abbreviation:  J. Stud. Alcohol     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-12     Completed Date:  1986-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503813     Medline TA:  J Stud Alcohol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-5     Citation Subset:  IM    
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MeSH Terms
Dietary Proteins*
Liver Cirrhosis / mortality*
Middle Aged
New Zealand
Uric Acid / blood*
Reg. No./Substance:
0/Dietary Proteins; 69-93-2/Uric Acid

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