Document Detail

Correlations between antepartum maternal metabolism and child intelligence.
MedLine Citation:
PMID:  1881416     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is not clear to what extent maternal metabolism during pregnancy affects the cognitive and behavioral function of the offspring by altering brain development in utero. To investigate this question, we correlated measures of metabolism in pregnant diabetic and nondiabetic women with the intellectual development of their offspring. METHODS: The study included 223 pregnant women and their singleton offspring: 89 women had diabetes before pregnancy (pregestational diabetes mellitus), 99 had the onset of diabetes during pregnancy (gestational diabetes mellitus), and 35 had normal carbohydrate metabolism during their pregnancy. We correlated measures of maternal glucose and lipid metabolism (fasting plasma glucose levels, hemoglobin A1c levels, episodes of hypoglycemia, episodes of acetonuria, and plasma beta-hydroxybutyrate and free fatty acid levels) with two measures of intellectual development in the offspring--the mental development index of the Bayley Scales of Infant Development, given at the age of two years, and the Stanford--Binet Intelligence Scale, given at the ages of three, four, and five years and expressed as an average of the three scores. RESULTS: After correction for socioeconomic status, race or ethnic origin, and patient group, the children's mental-development-index scores at the age of two years correlated inversely with the mothers' third-trimester plasma beta-hydroxybutyrate levels (r = -0.21, P less than 0.01); the average Stanford-Binet scores correlated inversely with third-trimester plasma beta-hydroxybutyrate (r = -0.20, P less than 0.02) and free fatty acid (r = -0.27, P less than 0.002) levels. No other correlations were significant. Including various perinatal events (e.g., prematurity and acidemia) in the analyses did not alter the results. CONCLUSIONS: Maternal diabetes during pregnancy may affect behavioral and intellectual development in the offspring. The associations between gestational ketonemia in the mother and a lower IQ in the child warrant continued efforts to avoid ketoacidosis and accelerated starvation in all pregnant women.
T Rizzo; B E Metzger; W J Burns; K Burns
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  325     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-30     Completed Date:  1991-09-30     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  911-6     Citation Subset:  AIM; IM    
Department of Medicine, Northwestern University Medical School, Chicago, IL.
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MeSH Terms
3-Hydroxybutyric Acid
Blood Glucose / metabolism
Child Development
Child, Preschool
Fatty Acids, Nonesterified / blood
Hemoglobin A / metabolism
Hydroxybutyrates / blood
Infant, Newborn
Pregnancy / metabolism*
Pregnancy in Diabetics / metabolism*
Stanford-Binet Test
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 300-85-6/3-Hydroxybutyric Acid; 9034-51-9/Hemoglobin A
Comment In:
N Engl J Med. 1991 Sep 26;325(13):959-60   [PMID:  1908948 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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