Document Detail

Correlations among gastric juice pH and ammonia, Helicobacter pylori infection and gastric mucosal histology.
MedLine Citation:
PMID:  15683108     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To assess the relationships among gastric pH and ammonia level, H. pylori infection, and gastric mucosal histology, we determined the gastric juice pH and ammonia concentration in H. pylori gastritis. METHODS: The pH levels and ammonia concentrations were determined in gastric juice collected from 143 patients with dyspepsia during an endoscopy and compared according to a H. pylori infection. We also looked for correlations between two chemical parameters, between each of these parameters and H. pylori density, and histology. RESULTS: Gastric pH levels and ammonia concentrations were higher in 94 infected patients than in the uninfected (3.16 vs. 1.55, p = 0.0001; 5.58 +/- 2.69 vs. 2.00 +/- 1.49 mol/L, p = 0.0001). Among 28 patients who received eradication therapy, 19 (67.9%) were successful, and their gastric pH levels and ammonia concentrations were significantly lower than those in the eradication failure group (1.60 vs. 2.33, p = 0.007; 1.77 +/- 1.28 vs. 4.02 +/- 1.20 micromoL/L, p = 0.0001). Gastric pH was significantly associated with intragastric ammonia concentration (p = 0.025) and gastritis activity (p = 0.018). Gastric pH and the ammonia level were significantly correlated with each other (rs = 0.495, p < 0.01), and with H. pylori density (rs = 0.467; rs = 0.735, p < 0.01), gastritis severity (rs = 0.343; rs = 0.478, p < 0.01), and gastritis activity (rs=0.418; rs = 0.579, p < 0.01). CONCLUSION: Gastric juice pH and ammonia concentration reflect well the status of a H. pylori infection, and significantly correlate with each other and with H. pylori density, gastritis severity and activity. These findings suggest that intragastric ammonia produced by H. pylori may have a partial role in an increased gastric juice pH, and has a pathogenic role in H. pylori gastritis.
Ok-Jae Lee; Eun-Jung Lee; Hyun-Jin Kim
Related Documents :
9479648 - Helicobacter pylori, neutrophils, interleukins, and gastric epithelial proliferation.
12139018 - Helicobacter pylori may survive ampicillin treatment in the remnant stomach.
11421878 - Predictors of failure of helicobacter pylori eradication with the standard 'maastricht ...
17032348 - Randomized comparison of two rescue therapies for helicobacter pylori infection.
4682638 - The infection hazard of contaminated nebulizers.
3503138 - Eimeria fraterculae sp. n. in the kidneys of atlantic puffins (fratercula arctica) from...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Korean journal of internal medicine     Volume:  19     ISSN:  1226-3303     ISO Abbreviation:  Korean J. Intern. Med.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-01     Completed Date:  2005-03-17     Revised Date:  2006-09-26    
Medline Journal Info:
Nlm Unique ID:  8712418     Medline TA:  Korean J Intern Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Department of Internal Medicine, Institute of Health Science, College of Medicine, Gyeong-Sang National University, Jinju, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ammonia / analysis*
Gastric Juice / chemistry*
Gastric Mucosa / pathology*
Gastritis / microbiology*
Helicobacter Infections / complications*
Hydrogen-Ion Concentration
Middle Aged
Severity of Illness Index
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Drug related problems identified by European community pharmacists in patients discharged from hospi...
Next Document:  Early assessment of myocardial contractility by contrast-enhanced magnetic resonance (ceMRI) imaging...