| Correlation with behavioral activity and rest implies circadian regulation by SCN neuronal activity levels. | |
MedLine Citation:
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PMID: 19926807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The SCN of the hypothalamus contains a major pacemaker, which exhibits 24-h rhythms in electrical impulse frequency. Although it is known that SCN electrical activity is high during the day and low during the night, the precise relationship between electrical activity and behavioral rhythms is almost entirely unknown. The authors performed long-term recordings of SCN multiple unit activity with the aid of implanted microelectrodes in parallel with the drinking activity in freely moving mice. The animals were kept in a 12h:12h light-dark cycle (LD 12:12) and in short-day (LD 8:16) and long-day photoperiods (LD 16:8). Onsets and offsets of behavioral activity occurred when SCN discharge was around half-maximum value. Of the onsets 80%, and of the offsets 62%, occurred when SCN electrical activity differed less than 15% from the half-maximum electrical activity levels. Transitions between rest and activity could be described by a sigmoid shaped probability curve with Hill coefficients of 7.0 for onsets and 5.7 for offsets. The similarity in the onset and offset levels shows an absence of hysteresis in the control of behavioral activity by the SCN. Exposure to short- or long-day photoperiods induced significant alterations in the waveform of electrical activity but did not affect SCN electrical activity levels at which behavioral transitions occurred. In all photoperiods, the SCN signal was skewed with more rapid discharge changes during onsets (19% per hour) than offsets (11% per hour). The precision of the circadian system appears optimized, as transitions between behavioral activity and rest occur when the change in SCN electrical activity is maximal, both during the declining and rising phase. The authors conclude that transitions in behavioral state can be described by a probability function around half-maximum electrical activity levels and that the parameters of the SCN, predicting onset and offset of behavior, are remarkably insensitive to environmental conditions. |
Authors:
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Thijs Houben; Tom Deboer; Floor van Oosterhout; Johanna H Meijer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biological rhythms Volume: 24 ISSN: 1552-4531 ISO Abbreviation: J. Biol. Rhythms Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700115 Medline TA: J Biol Rhythms Country: United States |
Other Details:
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Languages: eng Pagination: 477-87 Citation Subset: IM |
Affiliation:
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Department of Molecular Cell Biology, Leiden University Medical Centre, the Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology Biological Clocks / physiology Circadian Rhythm / physiology* Drinking Behavior / physiology Electrodes, Implanted Electrophysiological Phenomena Male Mice Mice, Inbred C57BL Motor Activity / physiology* Neurons / physiology* Photoperiod Rest / physiology* Suprachiasmatic Nucleus / physiology* |
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