| Correlation of vasoconstriction and kidney protection during shock wave lithotripsy. | |
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MedLine Citation:
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PMID: 18530715 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Kidney injury in lithotripsy can lead to long-term adverse effects, so minimizing injury is beneficial. We have found that injury is significantly reduced when shock wave (SW) administration is halted briefly- 3-minutes-early in treatment. Previous studies have shown that SWs stimulate renal blood vessels to constrict. Therefore, we tested the idea that vasoconstriction mediates SW-induced protection of the kidney. Doppler ultrasound was used to measure resistive index (RI), a ratio of systolic and diastolic velocities, indicating vasoconstriction. RI was determined for single intralobar arteries in targeted porcine kidneys treated by standard versus protection protocols (2,000SW, uninterrupted vs 500SW-3-min pause-2,000SW) using a Dornier-HM3 lithotripter (2Hz, 24kV). Significant differences in RI from baseline within a group and between groups at various time points were determined using mixed-effect models for repeated measures with Holm's step-down method for multiple comparison adjustment. All animals had similar baselines. Sham pigs (no-SWs) showed no significant change in RI. The protection protocol produced a significant rise (p<0.05, n=8) in RI 15 minutes into treatment, while the standard protocol did not yield a significant rise (p<0.05, n=7) until 45 minutes after treatment. Thus, the treatment protocol shown to protect against injury, induces early vasoconstriction. [NIH-DK43881, NSBRI-SMS00402]. |
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Authors:
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Michael R Bailey; Marla Paun; Rajash K Handa; Sujuan Gao; Lynn R Willis; Bret A Connors; James A McAteer; Andrew P Evan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 123 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-06-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 3367 Citation Subset: IM |
Affiliation:
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Center for Industrial and Medical Ultrasound, Applied Physics Lab., University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA, bailey@apl.washington.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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