| Correlation of type A behaviour with adrenergic receptor density: implications for coronary artery disease pathogenesis. | |
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MedLine Citation:
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PMID: 2889863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 17 healthy young men who had a parent with documented early coronary disease, ratings of type A behaviour correlated with upregulated lymphocyte beta 2 receptor density and inversely with the ratio of platelet alpha 2 to lymphocyte beta 2 receptor density ratio. This indicates a correlation of type A behaviour with receptor-based determinations of increased peripheral alpha-adrenergic balance, consistent with increased coronary arterial vasoconstriction, perhaps leading to coronary artery disease. |
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Authors:
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J P Kahn; A S Perumal; R J Gully; T M Smith; T B Cooper; D F Klein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lancet Volume: 2 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-11-27 Completed Date: 1987-11-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 937-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, College of Physicians and Surgeons, Columbia University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteriosclerosis / genetics Blood Platelets / analysis Coronary Disease / etiology*, genetics Cyclic AMP / blood Female Humans Interview, Psychological Isoproterenol / diagnostic use Lymphocytes / analysis Male Middle Aged Myocardial Infarction / genetics Receptors, Adrenergic, alpha / analysis* Receptors, Adrenergic, beta / analysis* Risk Factors Type A Personality* |
| Grant Support | |
ID/Acronym/Agency:
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MH 30906/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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