Document Detail

Correlation of type A behaviour with adrenergic receptor density: implications for coronary artery disease pathogenesis.
MedLine Citation:
PMID:  2889863     Owner:  NLM     Status:  MEDLINE    
In 17 healthy young men who had a parent with documented early coronary disease, ratings of type A behaviour correlated with upregulated lymphocyte beta 2 receptor density and inversely with the ratio of platelet alpha 2 to lymphocyte beta 2 receptor density ratio. This indicates a correlation of type A behaviour with receptor-based determinations of increased peripheral alpha-adrenergic balance, consistent with increased coronary arterial vasoconstriction, perhaps leading to coronary artery disease.
J P Kahn; A S Perumal; R J Gully; T M Smith; T B Cooper; D F Klein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-27     Completed Date:  1987-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  937-9     Citation Subset:  AIM; IM    
Department of Psychiatry, College of Physicians and Surgeons, Columbia University.
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MeSH Terms
Arteriosclerosis / genetics
Blood Platelets / analysis
Coronary Disease / etiology*,  genetics
Cyclic AMP / blood
Interview, Psychological
Isoproterenol / diagnostic use
Lymphocytes / analysis
Middle Aged
Myocardial Infarction / genetics
Receptors, Adrenergic, alpha / analysis*
Receptors, Adrenergic, beta / analysis*
Risk Factors
Type A Personality*
Grant Support
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

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