Document Detail

Correlation of thrombolysis in myocardial infarction (TIMI) risk score with extent of coronary artery disease in patients with acute coronary syndrome.
MedLine Citation:
PMID:  20225777     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the correlation of thrombolysis in myocardial infarction (TIMI) risk score with extent of coronary artery disease (CAD) in patients with acute coronary syndrome (ACS). METHODS: We conducted a descriptive study among 200 consecutive patients admitted with ACS at Tabba Heart Institute, Karachi from June to December 2008. The TIMI risk score was stratified on seven standard variables. The extent of CAD was evaluated on angiography and significant CAD was defined as > or =70% stenosis in any one of the three major epicardial vessels. RESULTS: The mean age of the sample was 58.53 +/- 10.64 years. Out of 200 patients, there were 142 (71%) patients with TIMI score < or =4 (low and intermediate TIMI risk score) and 58 (29%) patients with TIMI score >4 (high TIMI risk score). Patients with TIMI score >4 were more likely to have significant three vessel CAD (62%) versus those with TIMI risk score <4 (46.2%), (p < 0.04). CONCLUSION: Patients with high TIMI risk score were more likely to have severe multivessel CAD compared with those with low or intermediate TIMI risk score. Hence, patients with TIMI score >4 should be referred for early invasive coronary evaluation to derive clinical benefit.
Muhammad Shakir Lakhani; Faisal Qadir; Bashir Hanif; Salman Farooq; Moinuddin Khan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  60     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Department of Cardiology, Tabba Heart Institute, Ziauddin Medical University, Karachi, Pakistan.
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MeSH Terms
Acute Coronary Syndrome / diagnosis*,  physiopathology
Aged, 80 and over
Coronary Artery Disease / diagnosis*,  physiopathology
Coronary Stenosis
Cross-Sectional Studies
Diabetes Mellitus
Health Status Indicators
Middle Aged
Predictive Value of Tests
Risk Assessment
Severity of Illness Index
Smoking / adverse effects
Statistics as Topic
Thrombolytic Therapy

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