Document Detail

Correlation of serum progestagen-associated endometrial protein levels with endometrial biopsies serum steroid levels and therapy for luteal phase defects.
MedLine Citation:
PMID:  1918299     Owner:  NLM     Status:  MEDLINE    
The progestagen-associated endometrial protein (PEP) level rises from the early to the late luteal phase. A study was performed in infertile women where late luteal phase endometrial biopsies and serum PEP levels were obtained. The objective of the study was to evaluate the correlation between the PEP levels and the endometrial biopsies and to determine if subnormal PEP levels could be improved by the same therapies used to correct endometrial defects. There was a poor correlation between PEP levels and endometrial biopsies (r = 0.17). Similarly, there was no significant correlation between PEP levels and levels of the following hormones: mid- and late-luteal phase progesterone (P) (r = 0.186 and 0.282 respectively), mid-luteal phase 17-hydroxyprogesterone (17-OHP) (r = 0.139) and mid-luteal phase oestradiol (r = 0.135). Furthermore, there was no correlation between PEP levels and the dosage of progesterone used in therapy (r = 0.07). There were no statistically significant differences in PEP values (U/ml) depending on whether any fertility drug was taken. Thus our data suggest that progesterone may only have a permissive role, with some other factor(s) controlling the actual rise and fall of PEP.
J H Check; K Nowroozi; M L Check; B Vetter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  6     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-11-08     Completed Date:  1991-11-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  511-4     Citation Subset:  IM    
University of Medicine and Dentistry of New Jersey, Robert Wood Johnston Medical School, Camden.
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MeSH Terms
Bromocriptine / pharmacology
Clomiphene / pharmacology
Dose-Response Relationship, Drug
Estradiol / blood
Hydroxyprogesterones / blood
Infertility, Female* / drug therapy,  metabolism,  pathology
Luteal Phase / physiology*
Menotropins / pharmacology
Pregnancy Proteins / blood*
Progesterone / blood,  pharmacology
Reg. No./Substance:
0/Glycoproteins; 0/Hydroxyprogesterones; 0/PAEP protein, human; 0/Pregnancy Proteins; 25614-03-3/Bromocriptine; 50-28-2/Estradiol; 57-83-0/Progesterone; 61489-71-2/Menotropins; 68-96-2/17-alpha-Hydroxyprogesterone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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