| Correlation of serum hormone concentrations in maternal and umbilical cord samples. | |
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MedLine Citation:
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PMID: 12750241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence suggests that adult cancer risk of hormonally related tumors may be influenced by the in utero environment, and most speculation on the biological mechanism has focused on the hormonal component. Epidemiological studies investigating the biological nature of pregnancy and maternal factors associated with offspring's cancer risk have relied on maternal hormone measurements. The degree to which maternal hormone levels represent the fetal environment, however, is not widely known. Pregnancy estrogen, androstenedione, testosterone, dehydroepiandrosterone (DHEA), and DHEA-sulfate concentrations were measured in maternal and mixed umbilical cord sera from 86 singleton pregnancies. Spearman correlations between maternal and cord hormone levels generally ranged between 0.2 and 0.3. The correlation was 0.26 for estriol, the estrogen of highest concentration in pregnancy, and 0.27 for estradiol, the most biologically active estrogen. The correlations between mother and offspring for the estrogens and DHEA appeared similar for males and females, whereas there was a suggestion that the maternal-umbilical cord correlations for other androgens varied in magnitude by fetal sex, and all correlations appeared higher in pregnancies lasting <38 weeks compared with longer gestational lengths, although these stratified findings may have been attributable to chance. These data show a moderate degree of correlation in hormone concentrations between the maternal and fetal circulation. Studies using maternal hormone concentrations as a proxy for the fetal environment should consider the misclassification resulting with the use of this marker. |
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Authors:
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Rebecca Troisi; Nancy Potischman; James M Roberts; Gail Harger; Nina Markovic; Bernard Cole; David Lykins; Pentti Siiteri; Robert N Hoover |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 12 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-16 Completed Date: 2003-09-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 452-6 Citation Subset: IM |
Affiliation:
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA. troisir@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Androstenedione / blood Biological Markers / blood Case-Control Studies Dehydroepiandrosterone / blood Dehydroepiandrosterone Sulfate / blood Estradiol / blood Estriol / blood Estrone / blood Female Fetal Blood Hormones / blood* Humans Infant, Newborn Male Neoplasms / epidemiology, etiology Pennsylvania / epidemiology Pregnancy / blood* Testosterone / blood |
| Grant Support | |
ID/Acronym/Agency:
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2 P01 HD30367/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hormones; 50-27-1/Estriol; 50-28-2/Estradiol; 53-16-7/Estrone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 63-05-8/Androstenedione; 651-48-9/Dehydroepiandrosterone Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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