| Correlation of serum IL-13 and IL-5 levels with clinical response to Glatiramer acetate in patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 12930374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glatiramer acetate (GA) is effective in the treatment of Multiple Sclerosis (MS) presumably by the induction of an immunoregulatory T-cell response. We have previously shown that GA directly induces the Th2 cytokines IL-13 and IL-5 in T-cells in vitro. In the present study we compared the in vitro response to GA in healthy controls, untreated and GA-treated MS patients and tested whether the induction of IL-13 and IL-5 secretion is also detectable in the serum of 25 MS patients treated with GA. Patients were grouped into clinical responders and nonresponders in order to determine a possible correlation with the immunological response. As a result we found a significant increase of IL-13 in the serum of clinical GA-responders whereas IL-13 was not detectable in controls, untreated MS (P < 0.001) and nonresponders (P = 0.015). Similarly, GA-treatment increased serum levels of IL-5 (P = 0.001). The correlation of serum IL-5 and clinical response was also significant (P = 0.039), however, there was an overlap between the different groups. The selective induction of IL-13 and IL-5 but not IL-4 by GA treatment suggests that the specific biological functions of these cytokines might be important for the therapeutic mechanism of GA. Measurement of serum IL-13 and IL-5 levels is a simple and inexpensive tool for monitoring the response to GA in MS patients. |
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Authors:
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E Wiesemann; J Klatt; C Wenzel; F Heidenreich; A Windhagen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 133 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-21 Completed Date: 2003-10-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 454-60 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical School Hannover, Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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therapeutic use* Adult Analysis of Variance Disease Progression Enzyme-Linked Immunosorbent Assay / methods Female Humans Interleukin-13 / blood* Interleukin-5 / blood* Lymphocytes / immunology Male Middle Aged Multiple Sclerosis / drug therapy*, immunology* Peptides / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Interleukin-13; 0/Interleukin-5; 0/Peptides; 0/copolymer 1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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