| Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome. | |
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MedLine Citation:
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PMID: 12839379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology. AIM: To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS. METHODS: 5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men). RESULTS: The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers. CONCLUSIONS: Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS. |
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Authors:
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R K Singh; H P Pandey; R H Singh |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology Volume: 22 ISSN: 0254-8860 ISO Abbreviation: Indian J Gastroenterol Publication Date: 2003 May-Jun |
Date Detail:
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Created Date: 2003-07-03 Completed Date: 2003-09-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8409436 Medline TA: Indian J Gastroenterol Country: India |
Other Details:
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Languages: eng Pagination: 88-90 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Science, Institute of Medical Sciences, BHU, Varanasi 221 005. rakeshbhu@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anxiety / metabolism* Biological Markers / blood Colonic Diseases, Functional / complications, metabolism* Diarrhea / complications*, metabolism Humans India Male Middle Aged Monoamine Oxidase / metabolism* Serotonin / metabolism* Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-67-9/Serotonin; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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