Document Detail

Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome.
MedLine Citation:
PMID:  12839379     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology. AIM: To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS. METHODS: 5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men). RESULTS: The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers. CONCLUSIONS: Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.
R K Singh; H P Pandey; R H Singh
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  22     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-07-03     Completed Date:  2003-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  88-90     Citation Subset:  IM    
Department of Biochemistry, Faculty of Science, Institute of Medical Sciences, BHU, Varanasi 221 005.
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MeSH Terms
Anxiety / metabolism*
Biological Markers / blood
Colonic Diseases, Functional / complications,  metabolism*
Diarrhea / complications*,  metabolism
Middle Aged
Monoamine Oxidase / metabolism*
Serotonin / metabolism*
Statistics as Topic
Reg. No./Substance:
0/Biological Markers; 50-67-9/Serotonin; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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