Document Detail


Correlation properties of spontaneous motor activity in healthy infants: a new computer-assisted method to evaluate neurological maturation.
MedLine Citation:
PMID:  23712684     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Qualitative assessment of spontaneous motor activity in early infancy is widely used in clinical practice. It enables the description of maturational changes of motor behavior in both healthy infants and infants who are at risk for later neurological impairment. These assessments are, however, time-consuming and are dependent upon professional experience. Therefore, a simple physiological method that describes the complex behavior of spontaneous movements (SMs) in infants would be helpful. In this methodological study, we aimed to determine whether time series of motor acceleration measurements at 40-44 weeks and 50-55 weeks gestational age in healthy infants exhibit fractal-like properties and if this self-affinity of the acceleration signal is sensitive to maturation. Healthy motor state was ensured by General Movement assessment. We assessed statistical persistence in the acceleration time series by calculating the scaling exponent α via detrended fluctuation analysis of the time series. In hand trajectories of SMs in infants we found a mean α value of 1.198 (95 % CI 1.167-1.230) at 40-44 weeks. Alpha changed significantly (p = 0.001) at 50-55 weeks to a mean of 1.102 (1.055-1.149). Complementary multilevel regression analysis confirmed a decreasing trend of α with increasing age. Statistical persistence of fluctuation in hand trajectories of SMs is sensitive to neurological maturation and can be characterized by a simple parameter α in an automated and observer-independent fashion. Future studies including children at risk for neurological impairment should evaluate whether this method could be used as an early clinical screening tool for later neurological compromise.
Authors:
Sandra Waldmeier; Sebastian Grunt; Edgar Delgado-Eckert; Philipp Latzin; Maja Steinlin; Katharina Fuhrer; Urs Frey
Related Documents :
12438404 - Inhibition of neisseria gonorrhoeae by lactobacillus species that are commonly isolated...
9872134 - Gender distinctions and lateral asymmetry in the low-level auditory brainstem response ...
9713384 - Androgens and masculinization of genitalia in the spotted hyaena (crocuta crocuta). 2. ...
7377734 - Micturition cysto-urethrography. potential diagnostic pitfalls in the male infant.
11561714 - Impact of breast-feeding on giardia lamblia infections in bilbeis, egypt.
18436354 - A non-randomized vaccine effectiveness trial of accelerated infant hepatitis b immuniza...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-28
Journal Detail:
Title:  Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale     Volume:  -     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatric Neurology, University Children's Hospital Bern, PO-Box CH-3010, Bern, Switzerland, sandrawaldmeier@hotmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  To the end! Distribution of attention along a tool in peri- and extrapersonal space.
Next Document:  Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medi...