Document Detail


Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal anomalies.
MedLine Citation:
PMID:  9949219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective study compared the prenatal ultrasound (US) diagnosis with autopsy findings in 61 intact fetuses following induced abortion and 36 fragmented fetuses from dilatation and evacuation (D&E). In intact fetuses, complete agreement between US diagnosis and autopsy findings was achieved in 65.6% of cases in the central nervous system (CNS) and 47.5% in other somatic organ systems (SOS). There were major differences between US and autopsy findings involving the CNS in 6.5% of cases and SOS in 27.9%. Correlation was better for evaluation of renal anomalies (complete agreement in 63.6% of 11 suspected cases, 2 false-positive and no false-negative cases) than congenital heart disease (complete agreement in 27.3% of 11 suspected cases, 5 false-positive and 3 false-negative cases). In D&E specimens, a prenatal diagnosis of neural tube defect (NTD) was confirmed in 90% of cases. However, due to fragmentation of fetal parts, the US diagnosis in the CNS could not be confirmed totally (69.4%) or partially (2.8%) in fetuses with chromosomal abnormalities (ChA) or multiple congenital anomalies (MCA). Nonetheless, the US diagnosis of SOS was confirmed in six cases on D&E, including Meckel-Gruber syndrome, cystic hygroma, renal agenesis with contralateral renal dysplasia, cardiac defect, fetal hydrops, and tracheal atresia. Our results show that a thorough autopsy of an intact fetus after abortion is necessary to confirm prenatal diagnosis and allow proper management and counseling. The pathologic examination of D&E specimens can reliably confirm the US diagnosis of NTD, but it is very limited in identifying other fetal anomalies.
Authors:
C C Sun; K Grumbach; D T DeCosta; C M Meyers; J S Dungan
Related Documents :
20162869 - Two cases of 9p deletion syndrome and a case of partial trisomy 8 and partial monosomy 9p.
6854719 - Ultrasonographic findings in placenta increta.
18446039 - Rapid prenatal diagnosis of common aneuploidies in amniotic fluid using quantitative fl...
7651659 - Cloacal exstrophy sequence: an exceptional ultrasound diagnosis.
12882089 - Role of vascularization in determining the time of hypoxic-ischemic encephalopathy in t...
16053909 - Prader-willi syndrome with a karyotype 47,xy,+min(15)(pter->q11.1:) and maternal upd 15...
24736219 - Noma in a 4 year-old girl: a case report from chad.
3652769 - A new tube for single lung ventilation.
21965139 - Hepatocellular carcinoma presenting with multiple bone and soft tissue metastases and a...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  2     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-03-16     Completed Date:  1999-03-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-42     Citation Subset:  IM    
Affiliation:
Department of Pathology and Pediatrics, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / diagnosis
Abortion, Induced
Chromosome Aberrations / diagnosis
Chromosome Disorders
Congenital Abnormalities / diagnosis*,  pathology,  ultrasonography
Humans
Predictive Value of Tests
Retrospective Studies
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Abnormalities in central nervous system development in osteogenesis imperfecta type II.
Next Document:  Effects of cocaine on the placenta.