Document Detail

Correlation of prenatal events with the development of polymicrogyria.
MedLine Citation:
PMID:  7611049     Owner:  NLM     Status:  MEDLINE    
We report two cases of polymicrogyria in which maternal insults were well documented during the first half of the second trimester of pregnancy. The clinical histories, MR studies, and, in one patient, autopsy results were carefully reviewed, and the timing and nature of the injuries correlated with known developmental events at the time of the injury. Our results support the theory that polymicrogyria results from injury to, or disruption of normal cellular interactions at, the external limiting membrane (the "glial-pial barrier").
A J Barkovich; H Rowley; A Bollen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  16     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-11     Completed Date:  1995-08-11     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  822-7     Citation Subset:  IM    
Department of Radiology, University of California, San Francisco 94143-4690, USA.
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MeSH Terms
Abnormalities, Drug-Induced / diagnosis*,  pathology
Brain / abnormalities*,  drug effects,  pathology
Caffeine / administration & dosage,  adverse effects
Cerebral Cortex / abnormalities,  drug effects,  pathology
Child, Preschool
Ergotamine / administration & dosage,  adverse effects
Follow-Up Studies
Infant, Newborn
Magnetic Resonance Imaging*
Migraine Disorders / drug therapy
Paint / adverse effects
Pregnancy Trimester, Second
Prenatal Exposure Delayed Effects*
Reg. No./Substance:
113-15-5/Ergotamine; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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