| Correlation of positron emission tomography standard uptake value and pathologic specimen size in cancer of the head and neck. | |
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MedLine Citation:
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PMID: 18258379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To correlate positron emission tomography (PET) standard uptake value (SUV) with pathologic specimen size in patients with head-and-neck cancers. METHODS AND MATERIALS: Eighteen patients with Stage II-IVB head-and-neck cancer with 27 tumors who underwent PET and computed tomography (CT) imaging of the head and neck followed by surgical resection were selected for this study. Various SUV thresholds were examined, including the software default (SUV(def)), narrowing the window by 1 standard deviation (SD) of the maximum (SUV-1SD), and SUV cutoff values of 2.5 or greater (SUV2.5) and 40% or greater maximum (SUV40). Volumetric pathologic data were available for 12 patients. Tumor volumes based on pathologic examination (gold standard), CT, SUV(def), SUV-1SD, SUV2.5, and SUV40 were analyzed. RESULTS: PET identified five tumors not seen on CT. The sensitivity of PET for identifying primary tumors was 94% (17 of 18). The Sensitivity of PET for staging the neck was 90% (9 of 10), whereas the specificity was 78% (7 of 9). The SUV2.5 method was most likely to overestimate tumor volume, whereas SUV(def) and SUV-1SD were most likely to underestimate tumor volume. CONCLUSIONS: The PET scan provides more accurate staging of primary tumors and nodal metastases for patients with advanced head-and-neck cancer than CT alone. Compared with the gold standard, significant variability exists in volumes obtained by using various SUV thresholds. A combination of clinical, CT, and PET data should continue to be used for optimal treatment planning. The SUV40 method appears to offer the best compromise between accuracy and reducing the risk of underestimating tumor extent. |
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Authors:
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Ryan J Burri; Balasubramanya Rangaswamy; Lale Kostakoglu; Benjamin Hoch; Eric M Genden; Peter M Som; Johnny Kao |
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Publication Detail:
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Type: Journal Article Date: 2008-02-06 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 71 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-07-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 682-8 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA. ryan.burri@mountsinai.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Head and Neck Neoplasms / metabolism*, pathology, radionuclide imaging* Humans Image Interpretation, Computer-Assisted / methods* Iopamidol / diagnostic use*, pharmacokinetics* Lymphatic Metastasis Male Middle Aged Neoplasm Staging Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 62883-00-5/Iopamidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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