Document Detail


Correlation of periscreen strip results and white cell count in peritoneal dialysis peritonitis.
MedLine Citation:
PMID:  20591004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Monitoring of peritoneal dialysis (PD) peritonitis can be difficult for visually impaired patients. PeriScreen strips measure leukocyte esterase activity and this might be a useful objective test that can be performed by patients at home. METHODS: A prospective study of 138 episodes of peritonitis was undertaken. Effluent samples were analysed for white cell count (WCC) and PeriScreen score on days 3 and 5. Co-morbidity data were collated from these patients. RESULTS: Effluent WCC and PeriScreen results were found to correlate with the gold standard assessment of microbiology WCC count. A positive PeriScreen result on day 5 predicted that the episode of peritonitis would relapse after treatment with a sensitivity of 80% but with a poor specificity of 45%. Patients who cleared or relapsed their peritonitis could not be differentiated based on their burden of co-morbidity, Karnofsky scores, age, dialysis vintage or infective organism. CONCLUSION: PeriScreen strip analysis correlated with microscopic WCC of PD. However, analysis of PD effluent on day 5 of treatment is not a good test to risk stratify patients for relapsing peritonitis.
Authors:
Stanley Fan; Catherine Lane; Sally Punzalan
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of renal care     Volume:  36     ISSN:  1755-6686     ISO Abbreviation:  J Ren Care     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392167     Medline TA:  J Ren Care     Country:  France    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  N    
Affiliation:
Department of Renal Medicine and Transplantation, The Royal London and St Bartholomew's Hospitals, London, UK. s.fan@qmul.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Carboxylic Ester Hydrolases / metabolism*
Female
Great Britain
Humans
Leukocyte Count*
Male
Middle Aged
Peritoneal Dialysis / adverse effects*
Peritonitis / etiology,  prevention & control*
Predictive Value of Tests
Prospective Studies
Reagent Strips*
Recurrence
Self Administration*
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Reagent Strips; EC 3.1.-/leukocyte esterase; EC 3.1.1.-/Carboxylic Ester Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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