Document Detail

Correlation of pancreatic blood flow and high-energy phosphates during experimental pancreatitis.
MedLine Citation:
PMID:  7117326     Owner:  NLM     Status:  MEDLINE    
A dog model was used to measure the hemodynamic changes occurring during acute pancreatitis induced by intraductal injection of fresh trypsin-bile-blood mixture. Pancreatic blood flow was measured with 15-micrometer radioactive microspheres. Measurements of pancreatic adenosine triphosphate (ATP) and creatine phosphate (CP) were made under normal conditions and during acute hemorrhagic pancreatitis. Basal ATP and CP concentrations were 5.82 +/- 0.25 and 5.30 +/- 0.31 mmol/g wet tissue, respectively. Hemorrhagic pancreatitis was characterized by a severe reduction in pancreatic blood flow, followed by a 45% fall of ATP and a 70% lowering of CP. These results suggest that inadequate pancreatic tissue perfusion during acute pancreatitis results in a marked depletion of high-energy phosphate stores. We suspect this energy depletion reflects the progression of the disease from edematous to hemorrhagic pancreatitis and causes irreversible damage of pancreatic tissue.
H Becker; J Vinten-Johansen; G D Buckberg; H I Bugyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  14     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Adenosine Triphosphate / analysis*
Hemorrhage / chemically induced,  metabolism
Pancreas / blood supply*
Pancreatitis / chemically induced,  metabolism*
Phosphocreatine / analysis*
Regional Blood Flow
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

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