Document Detail


Correlation of oxygen delivery with central venous oxygen saturation, mean arterial pressure and heart rate in piglets.
MedLine Citation:
PMID:  16918656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Accurate assessment and monitoring of the cardiocirculatory function is essential during major pediatric and pediatric cardiac surgery. Invasive monitoring of cardiac output and oxygen delivery (DO(2)) is expensive and sometimes associated with adverse events. Measurement of central venous oxygen saturation (ScvO(2)) is less invasive and may reflect the DO(2). Therefore, we investigated the correlation of ScvO(2) with cardiac index (CI) and DO(2) and in comparison the more common monitored parameters heart rate (HR) and mean arterial pressure (MAP) with DO(2) in an animal experimental setting. METHODS: In five fasted, anesthetized and mechanically ventilated piglets CI (transpulmonary thermodilution), venous and arterial blood gases, HR and MAP was measured during normal conditions, volume loading, inotropic support, and exsanguination. RESULTS: In the five piglets 168 measurements could be performed. In a wide hemodynamic range (CI 22-335 ml x kg(-1) min(-1)) we found significant correlations of ScvO(2) with DO(2)) (r(2) = 0.91, P < 0.0001) and CI (r(2) = 0.88, P < 0.0001) and also between DO(2) and MAP (r = 0.86, P < 0.0001) and HR (r = 0.19, P < 0.05). CONCLUSIONS: ScvO(2) is a better parameter for indirect estimation of DO(2) than MAP and heart rate. Measurement of ScvO(2) is simple and does not necessitate additional invasive techniques. In the clinical setting ScvO(2) should be used in combination with other standard vital parameters, i.e. MAP, central venous pressure, lactate, base excess, and urine output.
Authors:
Wilhelm A Osthaus; Dirk Huber; Carsten Beck; Anja Roehler; Gernot Marx; Hartmut Hecker; Robert Sümpelmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  16     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  944-7     Citation Subset:  IM    
Affiliation:
Zentrum Anästhesiologie, Medizinische Hochschule Hannover, Hannover, Germany. osthaus.alexander@mh-hannover.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Heart Rate
Oxygen / metabolism*
Swine
Veins / metabolism
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

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