Document Detail

Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. Possible role for left ventricular remodelling.
MedLine Citation:
PMID:  14659769     Owner:  NLM     Status:  MEDLINE    
AIMS: Oxidative stress is implicated in the progression of heart failure, and matrix metalloproteinase (MMP) activity is increased in patients with congestive heart failure. We examined the role of oxidative stress on MMP activity in humans. METHODS AND RESULTS: We measured the MMP activity and the level of 8-iso-prostagandin F2alpha (8-iso-PGF2alpha), a specific and quantitative maker of oxidant stress, in the pericardial fluid (PF) in 47 consecutive patients with coronary artery disease who underwent coronary artery bypass surgery. Zymography of PF showed bands at 92-85kDa (MMP-9) and 72-65kDa (MMP-2). The MMP activity was expressed as the ratio to MMP-2 standard. MMP-2, MMP-9 and total gelatinolysis activities were positively correlated with left ventricular end-diastolic volume index (LVEDVI), and MMP-2 and total gelatinolysis activities were also positively correlated with LV end-systolic volume index. Moreover, MMP-2, MMP-9 and total gelatinolysis activities were all positively correlated with pericardial level of 8-iso-PGF2alpha. Also, LVDEVI was positively correlated with pericardial level of 8-iso-PGF2alpha. CONCLUSIONS: Oxidative stress may play an important role in the regulation of MMP activity. Augmented MMP activity may be involved in the development of ventricular remodelling in patients with coronary artery disease.
Kunihiko Kameda; Toshiro Matsunaga; Naoki Abe; Hiroyuki Hanada; Hiroshi Ishizaka; Hirotsugu Ono; Masayuki Saitoh; Kozo Fukui; Ikuo Fukuda; Tomohiro Osanai; Ken Okumura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  24     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-08     Completed Date:  2004-02-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2180-5     Citation Subset:  IM    
The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan.
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MeSH Terms
Coronary Artery Disease / enzymology,  etiology*
Matrix Metalloproteinases / metabolism*
Oxidative Stress / physiology*
Pericardium / chemistry
Prostaglandins A / analysis
Ventricular Remodeling / physiology*
Reg. No./Substance:
0/8-isoprostaglandin A2; 0/Prostaglandins A; EC 3.4.24.-/Matrix Metalloproteinases
Comment In:
Eur Heart J. 2003 Dec;24(24):2161-3   [PMID:  14659766 ]

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