Document Detail

Correlation of neonatal nucleated red blood cell counts in preterm infants with histologic chorioamnionitis.
MedLine Citation:
PMID:  9240578     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to compare the neonatal nucleated red blood cell counts in preterm infants in the presence and absence of clinical and histologic chorioamnionitis while controlling for gestational age and birth weight percentile. STUDY DESIGN: Nucleated red blood cell counts were obtained from preterm infants delivered after preterm labor or preterm premature rupture of membranes. Patients were divided on the basis of clinical and histologic chorioamnionitis. Nucleated red blood cell counts between groups were compared, and regression analysis controlling for gestational age and birth weight percentile was performed. RESULTS: Of 359 patients, both measures of infection status were significantly associated with increased nucleated red blood cell counts. In the regression analysis histologic chorioamnionitis retained significance, whereas clinical chorioamnionitis did not. CONCLUSIONS: Histologic chorioamnionitis produces an erythropoietic response in the fetus. Whether fetal erythropoiesis is a direct response to mediators of inflammation or whether it is the result of a rise in erythropoietin is unknown.
E Leikin; D Garry; P Visintainer; U Verma; N Tejani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  177     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-30     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, New York Medical College, Valhalla 10595, USA.
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MeSH Terms
Birth Weight / physiology
Chorioamnionitis / blood*,  pathology
Erythrocyte Count
Erythropoiesis / physiology
Erythropoietin / physiology
Fetal Blood / cytology*
Fetal Membranes, Premature Rupture / complications*
Gestational Age
Infant, Newborn
Infant, Premature / blood*,  physiology
Obstetric Labor, Premature / complications*
Regression Analysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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