Document Detail

Correlation of near-infrared spectroscopy with perfusion parameters at the hepatic and systemic levels in an endotoxemic shock model.
MedLine Citation:
PMID:  17006393     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To determine the correlation of near-infrared spectrophotometry (NIRS) readings from the liver surface with invasive measurements of blood flow and tissue perfusion parameters in an animal model of endotoxemic shock. MATERIAL/METHODS: Laparotomy was performed in 12 Yorkshire piglets, and ultrasound blood flow probes were placed on the hepatic artery and portal vein. Hepatic vein, portal vein, and femoral artery catheters were inserted for intermittent blood sampling, and a pulmonary artery catheter was inserted via the jugular vein for cardiac output measurements. Near-infrared spectrophotometry optodes were placed across the right hepatic lobe. Endotoxemic shock was induced by continuous infusion of Escherichia coli lipopolysaccharide 055: B5. Pearson correlations were calculated between the perfusion parameters and the near-infrared spectrophotometry (NIRS) readings. RESULTS: After endotoxemic shock induction, liver blood flow decreased from 144 +/- 36 to 62 +/- 24 ml*min(-1)*100 g(-1) and oxygen delivery to the liver decreased from 20 +/- 6 to 7 +/- 4 ml*min(-1)*100 g(-1). Near-infrared spectrophotometry readings of oxyhemoglobin concentration decreased by 11.7+/-15.1 micromol*L(-1), and readings of deoxyhemoglobin concentration increased by 12.3 +/- micromol*L(-1). There were significant correlations (p < 0.05 for r2 > 0.11) between the oxyhemoglobin readings and liver oxygen delivery (r2 = 0.58), liver blood flow (r2 = 0.73) and cardiac output (r2 = 0.80). Deoxyhemoglobin readings highly correlated (p < 0.05 for r2 > 0.11) with mixed venous lactate (r2 = 0.87) and with hepatic vein lactate (r2 = 0.82). CONCLUSIONS: Noninvasive near-infrared spectrophotometry measurements of hepatic oxyhemoglobin and deoxyhemoglobin correlate with liver hemodynamics as well as with global and specific organ perfusion parameters and may serve, in the future, as a useful tool to monitor tissue perfusion in septic patients.
Elhanan Nahum; Peter W Skippen; Roy E Gagnon; Andrew J Macnab; Erik D Skarsgard
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-25
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  12     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2006-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  BR313-7     Citation Subset:  IM    
Division of Pediatric Critical Care, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Cardiac Output / physiology*
Disease Models, Animal
Femoral Artery / physiology
Hepatic Artery / physiology
Liver / blood supply*,  metabolism
Oxygen / blood
Oxyhemoglobins / metabolism
Portal Vein / physiology
Pulmonary Artery / physiology
Regional Blood Flow / physiology*
Shock, Septic / etiology,  metabolism*
Spectroscopy, Near-Infrared*
Sus scrofa
Reg. No./Substance:
0/Oxyhemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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