Document Detail


Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings.
MedLine Citation:
PMID:  18973493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Heart rate recovery (HRR) has been identified as a reliable predictor of cardiac mortality, correlated with autonomic tone. In a model of sequential exercise testings, we investigated the reproducibility of HRR and the association between HRR modification and myocardial adaptation to ischemia. METHODS: We studied 128 patients (mean age 62 +/- 9 years, 83% males) with angiographically documented coronary artery disease (CAD) and a first positive exercise testing, who agreed to undergo a second exercise testing after 24 hours. RESULTS: HRR was increased from 25 +/- 10 beats/min at the first exercise testing to 30 +/- 13 beats/min at the second exercise testing (P < 0.001). Thereafter, participants were divided into two groups: Group I comprised 88 patients who presented augmentation of the HRR in the first compared to the second exercise testing, while group II comprised 40 patients who presented unchanged or reduced HRR. The rate-pressure product (RPP) at 1 mm ST-segment depression (ischemic threshold) at the second compared to the first exercise testing were significantly improved in group I patients (2345 +/- 3429 mmHg/min), while it was worsened in group II patients (-630 +/- 2510 mmHg/min) (P < 0.001). CONCLUSIONS: In a model of sequential exercise testings, myocardial adaptation to exercise-induced ischemia was associated with favorable modification of HRR.
Authors:
Andreas P Michaelides; Christos A Fourlas; George K Andrikopoulos; Charalambos Antoniades; Dimitrios Soulis; Evangelos Chatzistamatiou; Christodoulos I Stefanadis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  13     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  364-70     Citation Subset:  IM    
Affiliation:
First Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece. michaelides@freemail.gr
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Autonomic Nervous System / physiopathology
Coronary Angiography
Exercise Test*
Female
Heart Rate*
Humans
Ischemic Preconditioning, Myocardial
Male
Middle Aged
Myocardial Ischemia / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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