| Correlation of measurements from diffusion weighted MR imaging and FDG PET/CT in GIST patients: ADC versus SUV. | |
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MedLine Citation:
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PMID: 21955604 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: We investigated the correlation relationship between ADCs measured by MRI and SUVs measured by PET/CT of lesions on GIST (gastrointestinal stromal tumor) patients to verify if MR is able to replace or serve as an alternative to PET/CT in GIST staging and treatment monitoring. MATERIALS AND METHODS: Between September 2010 and January 2011, five patients with histologically proven metastatic GIST in Queen Mary Hospital, Hong Kong were enrolled into our study. All patients underwent both MRI and PET/CT scans at prognosis. Pearson's correlations of twenty-nine lesions were conducted between 5 pairs of ADCs and SUVs values. RESULTS: Lesions in the liver, peritoneum or bowel loops were found by PET/CT and no extra-abdominal lesion was identified. All twenty-nine lesions are identifiable by MRI with sensitivity of 100%. Significant inverse correlation were found between ADC(mean) and SUV(mean) (P=0.006), ADC(mean) and SUV(max) (P=0.010), ADC(min) and SUV(max) (P=0.014), ADC(min) and SUV(mean) (P=0.026), rADC(min) and rSUV(max) (P=0.047). CONCLUSION: DWI is comparable to PET/CT in visually detecting the GIST lesions' location. Significant inverse correlations were found between ADCs from DWIBS and SUVs from PET/CT on data of GIST patients. This finding demonstrates that DWI is potentially capable of offering similar information for diagnosis and treatment response evaluating in GIST's patients as PET/CT does. Furthermore, ADC(min), which is determined by single pixel, is not as reliable as ADC(mean), which is weighted average value of the whole lesion volume. |
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Authors:
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Chun Sing Wong; Nanjie Gong; Yiu-Ching Chu; Marina-Portia Anthony; Queenie Chan; Ho Fun Lee; Kent Man Chu; Pek-Lan Khong |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-26 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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