Document Detail

Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy.
MedLine Citation:
PMID:  15992992     Owner:  NLM     Status:  MEDLINE    
We correlated serial brain MRIs with neuropathological findings in a 16-year-old female whose autopsy was consistent with Wernicke's encephalopathy (WE). Diffusion-weighted imaging, diffusion coefficients mapping and neuropathology findings were suggested vasogenic edema in the periaqueductal and peri-the-fourth ventricular areas. This is the first documented case report to make this direct comparison. The characteristic WE changes in the mammillary body was also correlated with the findings of MRI with contrast enhancement. Bilateral cortical lesions revealed by MRI were atypical and rare in WE and were not evidenced by pathological changes.
Yo-Tsen Liu; Jong-Ling Fuh; Jiing-Feng Lirng; Anna Fen-Yau Li; Donald Ming-Tak Ho; Shuu-Jiun Wang
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-29
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  108     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2007-01-05     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  682-7     Citation Subset:  IM    
The Neurological Institute, Taipei Veterans General Hospital, #201 Shi-Pai Road, Sec 2, Taipei 11217, Taiwan.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Autonomic Nervous System Diseases / etiology,  physiopathology
Brain / metabolism,  pathology*,  physiopathology
Brain Edema / etiology,  pathology,  physiopathology
Brain Stem / blood supply,  pathology,  physiopathology
Cardiovascular Diseases / etiology,  physiopathology
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging / methods*
Early Diagnosis
Encephalomyelitis, Acute Disseminated / diagnosis,  therapy
Fatal Outcome
Intracranial Hemorrhages / etiology,  pathology,  physiopathology
Mamillary Bodies / blood supply,  pathology,  physiopathology
Methylprednisolone / therapeutic use
Treatment Failure
Vomiting / complications,  physiopathology
Wernicke Encephalopathy / etiology,  pathology*,  physiopathology
Reg. No./Substance:
0/Anti-Bacterial Agents; 83-43-2/Methylprednisolone

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