Document Detail

Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation.
MedLine Citation:
PMID:  23018306     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation.
METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and collagen depositions in the intima, and the infiltration of mast cells into the layers of the aorta. We correlated the findings with gender, age, race and cause of death.
RESULTS: The degree of atherosclerosis was significantly higher in the elderly. The aorta was thicker in the elderly and in cases with a cardiovascular cause of death. The thickness of the intima was significantly greater in the elderly, in males and in cases with a cardiovascular cause of death. The lipid content in the intima of the aorta was significantly higher in Caucasians. Older people and men had a significantly higher number of mast cells.
CONCLUSION: A macroscopic evaluation is a good indicator of the severity of atherosclerosis, but a more detailed analysis, namely evaluating the thickness of the layers of the aorta and the number of mast cells, may further elucidate the changes in the constituents of this vessel.
Mara Lúcia da Fonseca Ferraz; Douglas Montielle Silva Nascimento; João Paulo Hanel Rorato; Ana Paula Espindula; Lívia Ferreira Oliveira; Luciana Santos Ramalho; Maria Helena Soares; Camila Lourencine Cavellani; Flávia Aparecida Oliveira; Sanívia Aparecida de Lima Pereira; Rosana Rosa Miranda Corrêa; Vicente de Paula Antunes Teixeira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  67     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-06-19     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1071-5     Citation Subset:  IM    
Triângulo Mineiro Federal University, Uberaba, MG, Brazil.
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MeSH Terms
Age Factors
Aged, 80 and over
Atherosclerosis / pathology*
Biological Markers
Cause of Death
Collagen / analysis
Disease Progression
Mast Cells / pathology
Middle Aged
Severity of Illness Index
Sex Factors
Tunica Media / pathology*
Young Adult
Reg. No./Substance:
0/Biological Markers; 9007-34-5/Collagen

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