Document Detail

Correlation of lactic acid level, cell count and cytology in cerebrospinal fluid of patients with bacterial and non-bacterial meningitis.
MedLine Citation:
PMID:  3176884     Owner:  NLM     Status:  MEDLINE    
The relation between lactate concentration and cell count was determined in 394 CSF samples from unselected patients. In addition, a similar analysis was performed in 156 CSF samples from patients with bacterial and non-bacterial meningitis. The correlation between cell type and lactate level was also examined. The analysis demonstrated a significant linear increase in lactate showing high lactate levels at cell counts above 350 cells per microliter. Since the lactic acid concentration in bacterial meningitis increases linearly with the number of lactate-producing cells, it may be concluded that the increased lactate concentration results from CSF pleocytosis. If lactate levels are higher than the normal distribution, additional sources of lactate production such as cerebral hypoxia must be assumed.
H W Kölmel; M von Maravic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  78     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  6-9     Citation Subset:  IM    
Department of Neurology, Free University of Berlin, West Germany.
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MeSH Terms
Bacterial Infections / cerebrospinal fluid*
Encephalitis / cerebrospinal fluid*,  microbiology
Lactates / cerebrospinal fluid*
Lactic Acid
Leukocytes / metabolism*
Meningitis / cerebrospinal fluid*,  microbiology
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

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