Document Detail

Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease.
MedLine Citation:
PMID:  19306401     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the brain iron deposits in patients with Alzheimer's disease (AD) and healthy age-matched controls using phase imaging. MATERIALS AND METHODS: Twenty-six AD patients and 24 healthy controls were recruited. A three-dimensional high-resolution, gradient-echo sequence was used to acquire phase data in the coronal plane. A high-pass filter was used to remove the phase variation caused by field inhomogeneity. The regions evaluated included the bilateral putamen, globus pallidus, and the head and body of the hippocampus. RESULTS: Significantly lower phase values in both the basal ganglion and hippocampus were revealed in the AD group compared to the normal controls (P < 0.05). The phase value in the right side of the head of the hippocampus had a moderate positive correlation with the MMSE score (r= 0.603, P = 0.000) and a negative correlation with the duration of the disease (r = -0.677, P = 0.013). Using -0.0972 radians as an optimal cutoff value, the sensitivity and specificity for differentiation between AD and normal controls reached 95.8 and 80.8%, respectively. CONCLUSION: Phase imaging proved to be a useful method for the differentiation between normal controls and AD patients. An investigation of the excessive accumulation of iron in the hippocampus may help us better understand the pathologic process and neuropsychological dysfunction of AD disease.
Bei Ding; Ke-Min Chen; Hua-Wei Ling; Fei Sun; Xia Li; Tao Wan; Wei-Min Chai; Huan Zhang; Ying Zhan; Yong-Jing Guan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  29     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-26     Completed Date:  2009-05-28     Revised Date:  2010-04-30    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  793-8     Citation Subset:  IM    
Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
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MeSH Terms
Alzheimer Disease / metabolism*
Case-Control Studies
Globus Pallidus / metabolism
Hippocampus / metabolism*
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Iron / metabolism*
Prospective Studies
Putamen / metabolism
ROC Curve
Statistics, Nonparametric
Reg. No./Substance:
Comment In:
J Magn Reson Imaging. 2010 May;31(5):1282; author reply 1283   [PMID:  20432369 ]

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