| Correlation of intra-articular ankle pathology with cytokine biomarkers and matrix degradation products. | |
| | |
MedLine Citation:
|
PMID: 22995228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Articular cartilage degeneration is mediated by inflammatory cytokines and fragments of structural matrix proteins. Few studies have examined the role of these biomarkers in intra-articular pathology of the ankle. METHODS: Four groups of patients with increasing ankle pathology were enrolled. Group 1 included controls with no pain who underwent unrelated forefoot surgery. Group 2 included patients undergoing arthroscopy with intraoperative mild chondrosis. Group 3 included patients undergoing arthroscopy with moderate/severe chondrosis, osteochondral lesions, impingement, or loose bodies. Group 4 included positive controls with severe arthrosis undergoing ankle arthrodesis/arthroplasty. Ankle fluid was obtained by intra-articular aspiration and was assayed for IL-6, IFN-γ, MCP, MIP-1β, and fibronectin-aggrecan complex (FAC), a matrix-degradation marker. There were 36 patients total, 21 males and 15 females with a mean age 45 (±16; range 18 to 76) years and a mean VAS for pain of 4.7 (±3.5; range 0 to 9). In groups 1 through 4, there were 11, 6, 15 and 4 patients respectively. RESULTS: The mean values of MCP-1 were 49.8 (±8.0) for minimal pathology and 133.9 (±33.0) for substantial pathology (pg/ml). The mean values of the FAC were 2.83 (±1.16) for minimal pathology and 9.62 (±2.23) for substantial pathology (optical density at 450 nm). The groups differed significantly in age, preoperative VAS, FAC, IL-6, and MCP-1 (p<0.05). CONCLUSION: There are differences in FAC and MCP-1 with increasing grades of severity of intra-articular pathology. CLINICAL RELEVANCE: These tests may play a role in determining the necessity for arthroscopy or intra-articular procedures in equivocal candidates. |
| | |
Authors:
|
Thomas P San Giovanni; S Raymond Golish; Ariel Palanca; Lewis S Hanna; Gaetano J Scuderi |
Related Documents
:
|
15154708 - The usefulness of 99mtc sulfur colloid bone marrow scintigraphy combined with 111in leu... 9658728 - Use of recombinant granulocyte colony-stimulating factor in fanconi's anemia. 7235958 - Splenectomy for immune thrombocytopenic purpura. 23204188 - New retractor facilitates exposure of the vascular pedicles in chinese men with complex... 7632508 - Response of type i membranoproliferative glomerulonephritis to pulse methylprednisolone... 8520158 - Preventive effect of simultaneously infused lipid emulsion against thrombophlebitis dur... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Foot & ankle international. / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society Volume: 33 ISSN: 1071-1007 ISO Abbreviation: Foot Ankle Int Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-09-21 Completed Date: 2012-11-01 Revised Date: 2013-02-25 |
Medline Journal Info:
|
Nlm Unique ID: 9433869 Medline TA: Foot Ankle Int Country: United States |
Other Details:
|
Languages: eng Pagination: 627-31 Citation Subset: IM |
Affiliation:
|
UHZ Sports Medicine Institue, Coral Gables, FL, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aggrecans / metabolism* Analysis of Variance Ankle Joint / metabolism*, surgery Arthrodesis Arthroscopy Biological Markers / metabolism Cartilage Diseases / metabolism, surgery Cartilage, Articular / metabolism, surgery Case-Control Studies Cytokines / metabolism* Enzyme-Linked Immunosorbent Assay Female Fibronectins / metabolism* Humans Male Middle Aged Osteoarthritis / metabolism, surgery Severity of Illness Index Synovial Fluid / metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Aggrecans; 0/Biological Markers; 0/Cytokines; 0/Fibronectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New paradigm for patient-reported outcomes assessment in foot & ankle research: computerized adaptiv...
Next Document: Evidence-based indications for distraction ankle arthroplasty.