Document Detail

Correlation of intra-articular ankle pathology with cytokine biomarkers and matrix degradation products.
MedLine Citation:
PMID:  22995228     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Articular cartilage degeneration is mediated by inflammatory cytokines and fragments of structural matrix proteins. Few studies have examined the role of these biomarkers in intra-articular pathology of the ankle.
METHODS: Four groups of patients with increasing ankle pathology were enrolled. Group 1 included controls with no pain who underwent unrelated forefoot surgery. Group 2 included patients undergoing arthroscopy with intraoperative mild chondrosis. Group 3 included patients undergoing arthroscopy with moderate/severe chondrosis, osteochondral lesions, impingement, or loose bodies. Group 4 included positive controls with severe arthrosis undergoing ankle arthrodesis/arthroplasty. Ankle fluid was obtained by intra-articular aspiration and was assayed for IL-6, IFN-γ, MCP, MIP-1β, and fibronectin-aggrecan complex (FAC), a matrix-degradation marker. There were 36 patients total, 21 males and 15 females with a mean age 45 (±16; range 18 to 76) years and a mean VAS for pain of 4.7 (±3.5; range 0 to 9). In groups 1 through 4, there were 11, 6, 15 and 4 patients respectively.
RESULTS: The mean values of MCP-1 were 49.8 (±8.0) for minimal pathology and 133.9 (±33.0) for substantial pathology (pg/ml). The mean values of the FAC were 2.83 (±1.16) for minimal pathology and 9.62 (±2.23) for substantial pathology (optical density at 450 nm). The groups differed significantly in age, preoperative VAS, FAC, IL-6, and MCP-1 (p<0.05).
CONCLUSION: There are differences in FAC and MCP-1 with increasing grades of severity of intra-articular pathology.
CLINICAL RELEVANCE: These tests may play a role in determining the necessity for arthroscopy or intra-articular procedures in equivocal candidates.
Thomas P San Giovanni; S Raymond Golish; Ariel Palanca; Lewis S Hanna; Gaetano J Scuderi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Foot & ankle international     Volume:  33     ISSN:  1071-1007     ISO Abbreviation:  Foot Ankle Int     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2012-11-01     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  9433869     Medline TA:  Foot Ankle Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  IM    
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MeSH Terms
Aggrecans / metabolism*
Analysis of Variance
Ankle Joint / metabolism*,  surgery
Biological Markers / metabolism
Cartilage Diseases / metabolism,  surgery
Cartilage, Articular / metabolism,  surgery
Case-Control Studies
Cytokines / metabolism*
Enzyme-Linked Immunosorbent Assay
Fibronectins / metabolism*
Middle Aged
Osteoarthritis / metabolism,  surgery
Severity of Illness Index
Synovial Fluid / metabolism*
Young Adult
Reg. No./Substance:
0/Aggrecans; 0/Biological Markers; 0/Cytokines; 0/Fibronectins

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