| Correlation of initial food reactions to observed reactions on challenges. | |
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MedLine Citation:
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PMID: 14989389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Food allergies occur in 2% to 3% of the pediatric population. These reactions can vary from mild cutaneous manifestations to severe life-threatening reactions. Limited information is available on which specific factors may predict the severity of subsequent reactions. OBJECTIVE: To determine whether the organ system or the specific food involved in the initial allergic reaction predicts the outcome of subsequent food challenge. METHODS: Retrospective review of all food sensitive children who underwent food challenges at The Children's Hospital of Philadelphia, Philadelphia, PA, in a 5-year period (n = 998 challenges). The specific food, initial symptom on presentation, and reaction on open challenges were recorded. RESULTS: A total of 413 of 998 food challenges produced positive results. Milk, egg, and peanut were the most common foods to be associated with a positive challenge result. The most common presentation of food allergy was cutaneous followed by multiorgan reactions. Peanut, milk, and egg sensitivities were more likely to cause a multiple-organ system reaction on challenge than wheat or other foods. Patients with egg allergy were more likely to have a different reaction on rechallenge than other foods. CONCLUSIONS: Milk, egg, and peanut are the most common foods associated with food challenges. Patients will typically experience similar reaction on re-exposure to the initial reaction. However, multiple-organ system reactions can occur after any initial clinical presentation, with milk, egg, and peanut having more multiple-organ reactions than other foods. |
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Authors:
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Jonathan M Spergel; Janet L Beausoleil; Joel M Fiedler; Julie Ginsberg; Kyle Wagner; Nicholas A Pawlowski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 92 ISSN: 1081-1206 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-03-01 Completed Date: 2004-03-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 217-24 Citation Subset: IM |
Affiliation:
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Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. spergel@email.chop.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Animals Arachis hypogaea / immunology Child Child, Preschool Female Food Hypersensitivity / diagnosis, immunology* Humans Hypersensitivity / diagnosis, immunology* Infant Infant, Newborn Male Milk / immunology Ovum / immunology Predictive Value of Tests Retrospective Studies Skin Tests Statistics, Nonparametric |
| Comments/Corrections | |
Comment In:
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Ann Allergy Asthma Immunol. 2004 Feb;92(2):195-7
[PMID:
14989385
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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