Document Detail

Correlation of initial food reactions to observed reactions on challenges.
MedLine Citation:
PMID:  14989389     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Food allergies occur in 2% to 3% of the pediatric population. These reactions can vary from mild cutaneous manifestations to severe life-threatening reactions. Limited information is available on which specific factors may predict the severity of subsequent reactions. OBJECTIVE: To determine whether the organ system or the specific food involved in the initial allergic reaction predicts the outcome of subsequent food challenge. METHODS: Retrospective review of all food sensitive children who underwent food challenges at The Children's Hospital of Philadelphia, Philadelphia, PA, in a 5-year period (n = 998 challenges). The specific food, initial symptom on presentation, and reaction on open challenges were recorded. RESULTS: A total of 413 of 998 food challenges produced positive results. Milk, egg, and peanut were the most common foods to be associated with a positive challenge result. The most common presentation of food allergy was cutaneous followed by multiorgan reactions. Peanut, milk, and egg sensitivities were more likely to cause a multiple-organ system reaction on challenge than wheat or other foods. Patients with egg allergy were more likely to have a different reaction on rechallenge than other foods. CONCLUSIONS: Milk, egg, and peanut are the most common foods associated with food challenges. Patients will typically experience similar reaction on re-exposure to the initial reaction. However, multiple-organ system reactions can occur after any initial clinical presentation, with milk, egg, and peanut having more multiple-organ reactions than other foods.
Jonathan M Spergel; Janet L Beausoleil; Joel M Fiedler; Julie Ginsberg; Kyle Wagner; Nicholas A Pawlowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  92     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-01     Completed Date:  2004-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
Arachis hypogaea / immunology
Child, Preschool
Food Hypersensitivity / diagnosis,  immunology*
Hypersensitivity / diagnosis,  immunology*
Infant, Newborn
Milk / immunology
Ovum / immunology
Predictive Value of Tests
Retrospective Studies
Skin Tests
Statistics, Nonparametric
Comment In:
Ann Allergy Asthma Immunol. 2004 Feb;92(2):195-7   [PMID:  14989385 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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