| Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide. | |
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MedLine Citation:
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PMID: 15993935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibition of nitric oxide synthase (NOS) antagonizes nitrous oxide (N2O)-induced antinociception in mice. This study was conducted to compare brain NOS activity in high responding C57BL/6 mice, low responding DBA/2 mice and S5 mice selectively bred for low responsiveness to N2O. Exposure to 70% N2O suppressed acetic acid-induced abdominal constrictions in C57BL/6 mice but not DBA/2 or S5 mice. N2O exposure also elevated NOS activity in brains of C57BL/6 mice but not DBA/2 or S5 mice. The absence of these effects in DBA/2 or S5 mice is further support for the hypothesis that nitric oxide (NO) may play a critical role in N2O-induced antinociception in mice. |
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Authors:
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Elisabeth Day Henry; Yusuke Ohgami; Shuang Li; Eunhee Chung; Raymond M Quock |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 81 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-11-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 764-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Non-Narcotic
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pharmacology* Animals Brain / drug effects*, enzymology Cerebellum / drug effects, enzymology Corpus Striatum / drug effects, enzymology Female Inbreeding Male Mice Mice, Inbred C57BL Mice, Inbred DBA Nitric Oxide Synthase / genetics, metabolism* Nitrous Oxide / pharmacology* Pain Measurement / methods Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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DA-10047/DA/NIDA NIH HHS; DA10343/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 10024-97-2/Nitrous Oxide; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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