| Correlation of immunological profile with phenotype and disease outcome in pemphigus. | |
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MedLine Citation:
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PMID: 20574606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There has been no previous clinical-immunological study of pemphigus in Spain. The aim of this study was to perform a retrospective analysis of pemphigus patients who had been followed for a period of 18 years in our centre. We characterized the autoantibody response, compared diagnostic assays and correlated the immunobiological data with phenotype and prognosis. Clinical, epidemiological and immunopathological data were collected from 40 patients. Patients sera were characterized by indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). Epidemiological and clinical findings were comparable to other series. Mortality during follow-up was 0% and 6% in pemphigus foliaceus and vulgaris, respectively. Importantly, higher indirect immunofluorescence titres and anti-desmoglein 3 ELISA values of samples from untreated patients correlated significantly with a potentially worse clinical course. Moreover, there was a positive correlation between indirect immunofluorescence titres and anti-desmoglein 3 ELISA levels in pemphigus vulgaris patients. Based on our findings, initial high anti-desmoglein 3 antibodies in pemphigus patients correlate with a more adverse prognosis, which raises the question as to whether a more aggressive initial therapy is indicated in patients with this immunological pattern. |
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Authors:
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Josep E Herrero-González; Pilar Iranzo; Daniel Benítez; Francisco Lozano; Carmen Herrero; José M Mascaró |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 90 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-10-12 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 401-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, IMIM-Hospital del Mar, Barcelona, Spain. jherrero@parcdesalutmar.cat |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Autoantibodies / blood* Biological Markers / blood Desmoglein 1 / immunology Desmoglein 3 / immunology Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique, Indirect Humans Immunophenotyping Male Middle Aged Pemphigus / diagnosis, immunology*, mortality, therapy Phenotype Predictive Value of Tests Retrospective Studies Severity of Illness Index Spain Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Biological Markers; 0/DSG1 protein, human; 0/DSG3 protein, human; 0/Desmoglein 1; 0/Desmoglein 3 |
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