Document Detail


Correlation of immunological profile with phenotype and disease outcome in pemphigus.
MedLine Citation:
PMID:  20574606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There has been no previous clinical-immunological study of pemphigus in Spain. The aim of this study was to perform a retrospective analysis of pemphigus patients who had been followed for a period of 18 years in our centre. We characterized the autoantibody response, compared diagnostic assays and correlated the immunobiological data with phenotype and prognosis. Clinical, epidemiological and immunopathological data were collected from 40 patients. Patients sera were characterized by indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). Epidemiological and clinical findings were comparable to other series. Mortality during follow-up was 0% and 6% in pemphigus foliaceus and vulgaris, respectively. Importantly, higher indirect immunofluorescence titres and anti-desmoglein 3 ELISA values of samples from untreated patients correlated significantly with a potentially worse clinical course. Moreover, there was a positive correlation between indirect immunofluorescence titres and anti-desmoglein 3 ELISA levels in pemphigus vulgaris patients. Based on our findings, initial high anti-desmoglein 3 antibodies in pemphigus patients correlate with a more adverse prognosis, which raises the question as to whether a more aggressive initial therapy is indicated in patients with this immunological pattern.
Authors:
Josep E Herrero-González; Pilar Iranzo; Daniel Benítez; Francisco Lozano; Carmen Herrero; José M Mascaró
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  90     ISSN:  1651-2057     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-24     Completed Date:  2010-10-12     Revised Date:  2012-01-02    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, IMIM-Hospital del Mar, Barcelona, Spain. jherrero@parcdesalutmar.cat
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Autoantibodies / blood*
Biological Markers / blood
Desmoglein 1 / immunology
Desmoglein 3 / immunology
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique, Indirect
Humans
Immunophenotyping
Male
Middle Aged
Pemphigus / diagnosis,  immunology*,  mortality,  therapy
Phenotype
Predictive Value of Tests
Retrospective Studies
Severity of Illness Index
Spain
Time Factors
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/DSG1 protein, human; 0/DSG3 protein, human; 0/Desmoglein 1; 0/Desmoglein 3

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