| Correlation of house dust mite-specific lymphocyte proliferation with IL-5 production, eosinophilia, and the severity of symptoms in infants with atopic dermatitis. | |
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MedLine Citation:
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PMID: 9449505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because house dust mite (HDM)-specific IgE antibody (IgE-RAST) is usually not detectable in infants with atopic dermatitis (AD), HDM has not been regarded as the cause of infantile AD. The level of HDM-specific lymphocyte proliferation (expressed as stimulation index measured by flow cytometry [SIF]), however, was found to be markedly elevated in AD infants. This suggests that the sensitization of T cells to HDM extract occurs even in infancy. Moreover, the level of HDM-SIF is correlated closely with the severity of infantile AD, suggesting that HDM is a major cause of this disease not only in adults and children but also in infants. Although the level of HDM-SIF did not correlate with the level of HDM-specific IgE-RAST in infants with AD, it did intimately correlate with the absolute number of peripheral blood eosinophils. Because T lymphocytes are known to secrete some cytokines, such as IL-5, that enhance the proliferation of eosinophils, we measured the IL-5 production by peripheral blood mononuclear cells in infants with AD on stimulation with HDM extract. The amount of IL-5 production is significantly higher in infants with AD, as well as in children with AD, than that found in nonatopic control subjects. Moreover, the level of IL-5 production is correlated closely with the level of HDM-SIF in infants with AD. Taken together, these results suggest that HDMs play an important role in the development of infantile AD by inducing IL-5 production from HDM-specific T lymphocytes. |
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Authors:
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M Kimura; S Tsuruta; T Yoshida |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 101 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-05 Completed Date: 1998-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 84-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital, Urushiyama, Shizuoka City, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Allergens / adverse effects Animals Candida albicans / immunology Child Child, Preschool Dermatitis, Atopic / etiology*, immunology Dust / adverse effects* Eosinophilia / etiology*, immunology Humans Immunoglobulin E / blood Infant Interleukin-5 / biosynthesis* Lymphocyte Activation* Mites / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Dust; 0/Interleukin-5; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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