Document Detail


Correlation of homocytsteine levels with the extent of coronary atherosclerosis in patients with low cardiovascular risk profiles.
MedLine Citation:
PMID:  11078236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevation of homocysteine is now known as an independent risk factor for vascular diseases. However, influences of homocysteine to the extent of coronary atherosclerosis in patients with different coronary risk profiles have not been studied. In this study, we used angiographic "diffuse score" and "clinical vessel score" to evaluate the extent of coronary atherosclerosis, and examined the correlation between levels of serum total homocysteine and angiographic scores among patients with high- and low-risk profiles. Seventy consecutive patients (58 men and 12 women, mean age 50 years) undergoing selective coronary angiography for the first time were recruited for this study. Patients were divided into high-risk (risk factor > or =3, n = 35) and low-risk (risk factor <3, n = 35) groups. Linear regression analysis revealed that levels of serum homocysteine were only significantly correlated with diffuse (r = 0.217, p = 0.007) and clinical vessel (r = 0.078, p = 0.037) scores in low-risk patients. These correlations could not be observed in diffuse (r = 0.070, p = 0.319) and clinical vessel (r = -0.001, p = 0.970) scores in the high-risk group. In conclusion, levels of homocysteine correlated with the extent of coronary atherosclerosis only among patients with low cardiovascular risk profiles.
Authors:
W C Tsai; Y H Li; L M Tsai; T H Chao; L J Lin; T Y Chen; J H Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  The American journal of cardiology     Volume:  85     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Coronary Angiography
Coronary Artery Disease / classification,  etiology*,  radiography
Diabetes Complications
Female
Homocysteine / blood*
Humans
Hypercholesterolemia / complications
Hyperhomocysteinemia / blood*,  complications*
Hypertension / complications
Linear Models
Male
Middle Aged
Risk Factors
Severity of Illness Index*
Smoking / adverse effects
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

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